Publications by authors named "Suresh Narayanan Nair"

Objective: Various topographical classifications for craniopharyngioma have been proposed based on their relationship with optic chiasm and the third ventricular floor. There is a paucity of literature evaluating the surgical outcome based on tumor topography. This study aims to compare the surgical outcomes of retrochiasmatic craniopharyngiomas (RCPs) and nonretrochiasmatic craniopharyngiomas (non-RCPs).

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Introduction: Surgical management of craniopharyngioma is debatable and still lacks clear guidelines. Long-term complications are attributed to radical resection of the tumor. Extent of resection may not be the only factor which determines the functional outcome, because studies have reported hypothalamic and visual morbidities even with conservative resection.

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Prostaglandins are a group of important cell-signaling molecules involved in the regulation of ovarian maturation, oocyte development, egg laying and associated behaviors in invertebrates. However, the presence of prostaglandin E (PGE), the key enzymes for PGE biosynthesis and its interference by drugs were not investigated previously in the ovary of ticks. The present study was undertaken to assess the modulation of the PGE-mediated pathway in the eclosion blocking effect of flumethrin and terpenoid subfraction isolated from in ticks.

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Amitraz, a member of the formamidine pesticide family, commonly used for ectoparasite control, is applied as a dip or low-pressure hand spray to cattle and swine, and the neck collar on dogs. Data on amitraz were generated mainly on laboratory animals, hens, dogs, and baboons. The data on the toxicity and disposition of amitraz in animals and its residues in the milk are inadequate.

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Azithromycin is a macrolide antimicrobial agent of the azalide group with a broad spectrum of activity against gram-negative and gram-positive bacterial organisms. Tolfenamic acid is a non-steroidal anti-inflammatory drug of the fenamate group, which is used extensively in humans and animals due to its anti-inflammatory, analgesic, and antipyretic properties. There is dearth of literature on any type of drug interaction between azithromycin and tolfenamic acid in any species, including human beings and alteration of its pharmacokinetics by fever.

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Article Synopsis
  • - Humans have historically utilized various plant parts for preventing and treating illnesses, with many plants containing beneficial secondary metabolites known for their biological activities, such as antitumor and anti-inflammatory effects.
  • - The study focuses on Pamp. (Compositae), a plant used in southern India for controlling pests, particularly assessing the acaricidal activity of its ethanolic leaf extract against ticks, which are known to spread serious diseases and negatively impact livestock production.
  • - Chemical tick control methods face challenges like high costs and environmental risks, making plant-based formulations a promising alternative, with prior research supporting the efficacy of various medicinal plants in combatting ectoparasites.
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  • The study examines the impact of giant craniopharyngiomas (tumors larger than 4 cm) on surgical outcomes and survival rates.
  • A total of 44 patients were analyzed, showing a lower gross total resection (GTR) rate and higher postoperative complications in those with giant tumors compared to smaller ones.
  • Despite these challenges, the recurrence rates and overall survival did not significantly differ between giant and non-giant tumors, indicating that tumor size is a crucial factor in predicting functional outcomes post-surgery.
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Objective: The optimal therapeutic approach to craniopharyngioma has not been established conclusively. The surgical outcome following radical excision and conservative resection with adjuvant radiotherapy are comparable or even better with the later in pediatric or mixed populations. This study is aimed at reviewing the role of extent of resection in local tumor control and long-term outcome in adults with craniopharyngioma.

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The objective of the present study was to detect the chosen nucleotide DNA or RNA sequences of the pathogens in ticks of domestic and wild animals of Kerala, South India based on molecular techniques. Among 602 ticks collected, 413 were from bovines (cattle and buffalo), 26 from goats, 101 from dogs and 62 from wild animals. Amblyomma integrum, Am.

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The present study compares the in vitro efficacy of four chemical acaricides, viz. amitraz, coumaphos, deltamethrin and lindane, against Rhipicephalus (Boophilus) annulatus and Haemaphysalis bispinosa ticks based on adult immersion tests. Amitraz, at 350 ppm, elicited 29.

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  • This study followed 14 patients treated for spinal hemangioblastomas to understand their clinical profiles, surgical complications, and long-term outcomes.
  • Despite being benign tumors, spinal hemangioblastomas can lead to significant neurological issues, and 50% of the patients in the study were found to have von Hippel-Lindau (VHL) disease, which is linked to these tumors.
  • The results highlighted that while immediate postoperative neurological decline was common, by the 5-year follow-up, 78.57% of patients had positive functional outcomes after complete tumor removal.
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  • The study evaluated the acaricidal effects of caffeic acid, nortriptyline, precocene I, and quercetin on the tick species Rhipicephalus annulatus.
  • The adult immersion technique was used to test the compounds at various concentrations for their impact on tick mortality, reproductive index, fecundity, and egg hatching.
  • Results showed that while quercetin had the most significant effect by blocking egg hatching at higher concentrations, overall, the compounds demonstrated very low adult mortality and limited inhibition of fecundity.
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Commercially available preparations of cypermethrin (Clinar and Ectomin) and fenvalerate (Flytik and Ticomax, 20% E.C) were compared for their acaricidal activity against Rhipicephalus (Boophilus) annulatus using adult immersion test. Adult tick mortality was higher with Ectomin compared to Clinar.

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The pattern of mortality of Haemaphysalis bispinosa ticks against fipronil was studied based on adult immersion test. Mortality occurred during 10-19 days post-treatment. The LC50 and LC95 values were calculated as 0.

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The problems associated with synthetic chemical pesticides include resistance, residues, pest resurgence and the adverse effects on non-target organisms. Hence, many ecofriendly newer alternatives are being evaluated among which one of the most important is the use of herbal agents. Many of the plant extracts or its fractions are dissolved in polar or non polar solvents or detergents before tested for acaricidal activity.

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Using adult immersion test, the acaricidal activity of ethanolic extracts of leaves of Cassia alata L. was studied against Rhipicephalus (Boophilus) annulatus. The efficacy was assessed by measuring per cent adult mortality, inhibition of fecundity and hatching rate.

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