Long-Term Efficacy and Safety of Paliperidone 6-Month Formulation: An Open-Label 2-Year Extension of a 1-Year Double-Blind Study in Adult Participants With Schizophrenia.

Background: Paliperidone palmitate 6-month (PP6M) demonstrated noninferiority to paliperidone palmitate 3-month in preventing relapse in patients with schizophrenia in a phase 3 double-blind (DB) study (NCT03345342). Here, we report long-term efficacy and safety results from a 2-year single-arm, open-label extension (OLE; NCT04072575) of this DB study.

Methods: Participants who completed the DB study without relapse were enrolled and followed-up every 3 months up to 2 years.

Alginate-based drug carrier systems to target inflammatory bowel disease: A review.

Inflammatory bowel disease (IBD) is an inflammatory disorder that affects the gastrointestinal tract. IBD has become an increasingly common condition in both developed and developing nations over the last few decades, owing to a variety of factors like a rising population and diets packed with processed and junk foods. While the root pathophysiology of IBD is unknown, treatments are focused on medications aimed to mitigate symptoms.

Effect of variations in the conserved residues E371 and S359 on the structural dynamics of protein Z dependent protease inhibitor (ZPI): a molecular dynamic simulation study.

Protein Z (PZ) dependent protease inhibitor (ZPI) is a natural anticoagulant inhibiting blood coagulation proteases fXa and fXIa. Despite being a member of the serpin superfamily, it possesses unique structural features such as activation by PZ, regulating its inhibitory function. In order to understand the Reactive Centre Loop (RCL) dynamics of ZPI, which is absolutely critical for its activity, we performed Molecular Dynamics (MD) simulation on ZPI and its E371 and S359 variants located at important conserved functional sites.

Recent advancements in the synthesis of novel thermostable biocatalysts and their applications in commercially important chemoenzymatic conversion processes.

Thermostable enzymes are a field of growing interest in bioremediation, pharmaceuticals, food industry etc., due to their ability to catalyze bio reactions at high temperatures. This review aims to provide an overview on extremophiles with a special focus on thermophiles and enzymes produced from extremophilic bacteria.

Enhancing iCVD Modification of Electrospun Membranes for Membrane Distillation Using a 3D Printed Scaffold.

Electrospun membranes have shown promise for use in membrane distillation (MD) as they exhibit exceptionally low vapor transport. Their high porosity coupled with the occasional large pore can make them prone to wetting. In this work, initiated chemical vapor deposition (iCVD) is used to modify for electrospun membranes with increased hydrophobicity of the fiber network.

Anemia and thrombocytopenia in patients undergoing chemotherapy for solid tumors: a descriptive study of a large outpatient oncology practice database, 2000-2007.

Objective: This study was conducted to evaluate data on chemotherapy-associated anemia and thrombocytopenia, and cycle delays in patients with cancer in a community oncology practice.

Methods: Data on adult patients (age > or =18 years) with cancer treated in outpatient oncology clinics throughout the United States between 2000 and 2007 were obtained from a large electronic medical records database. All types of cancer were included, although the focus was on solid cancers (ie, lung, breast, ovarian, head and neck, and colorectal cancers).

Impact of illegal trade on the quality of epoetin alfa in Thailand.

Background: Reports from the World Health Organization have suggested that counterfeit medicines pose a serious problem in developing countries. An investigation of anti-erythropoietin antibody-mediated pure red cell aplasia in Thailand found evidence of drug smuggling, which may have serious safety implications.

Objective: This study assessed the authenticity and quality of epoetin alfa samples in Thailand.