Publications by authors named "Surabhi L Iyer"
Article Synopsis
- Vaccination status (vaccinated vs. unvaccinated) influences protective immunity against SARS-CoV-2 variants, particularly Delta and Omicron.
- Higher viral loads during infection correlate with lower antibody responses, highlighting the relationship between viral exposure and immune response.
- Convalescent antibody responses vary by variant: vaccinated individuals generally have stronger neutralization against variants, while unvaccinated responses are weaker, with specific differences noted between Delta and Omicron variants.
We enrolled 7 individuals with recurrent symptoms or antigen test conversion following nirmatrelvir-ritonavir treatment. High viral loads (median 6.1 log10 copies/mL) were detected after rebound for a median of 17 days after initial diagnosis.
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- There is evidence that the risk of getting infected with SARS-CoV-2 varies based on the variant, affecting how well vaccines protect against the virus.
- Researchers analyzed vaccinated and unvaccinated individuals with Delta or Omicron infections, measuring viral loads and antibodies.
- Results showed vaccinated individuals had higher neutralizing antibody levels than unvaccinated ones, and responses were variant-specific, with the Delta variant showing weaker responses against BA.2 and Omicron generating broader protection against multiple variants.
Clinical features of SARS-CoV-2 Omicron variant infection, including incubation period and transmission rates, distinguish this variant from preceding variants. However, whether the duration of shedding of viable virus differs between omicron and previous variants is not well understood. To characterize how variant and vaccination status impact shedding of viable virus, we serially sampled symptomatic outpatients newly diagnosed with COVID-19.
View Article and Find Full Text PDFEndothelial Mineralocorticoid Receptors Contribute to Vascular Inflammation in Atherosclerosis in a Sex-Specific Manner.
Arterioscler Thromb Vasc Biol
August 2019
Objective: MR (mineralocorticoid receptor) activation is associated with cardiovascular ischemia in humans. This study explores the role of the MR in atherosclerotic mice of both sexes and identifies a sex-specific role for endothelial cell (EC)-MR in vascular inflammation. Approach and Results: In the AAV-PCSK9 (adeno-associated virus-proprotein convertase subtilisin/kexin type 9) mouse atherosclerosis model, MR inhibition attenuated vascular inflammation in males but not females.
View Article and Find Full Text PDFElevated levels of the hormone aldosterone are associated with increased risk of myocardial infarction and stroke in humans and increased progression and inflammation of atherosclerotic plaques in animal models. Aldosterone acts through the mineralocorticoid receptor (MR) which is expressed in vascular smooth muscle cells (SMCs) where it promotes SMC calcification and chemokine secretion . The objective of this study is to explore the role of the MR specifically in SMCs in the progression of atherosclerosis and the associated vascular inflammation in the apolipoprotein E knockout (ApoE) mouse model.
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