Determination of essential oil and phenolic compounds of grown in Şavşat, Artvin; revealing its antioxidant and antimicrobial activities.

This study is to determine the antioxidant capacities, fatty acids and phenolic compounds, and antimicrobial activity in The antioxidant contents of the plants were determined using the CUPRAC, FRAP, and DPPH methods. The total phenolic content was determined using the Folin-Ciocalteu method, the phenolic compound profile was analyzed by HPLC, and the antimicrobial activity was assessed using the liquid microdilution method. The total polyphenol content was found to be 27.

Predicting Severe Respiratory Failure in Patients with COVID-19: A Machine Learning Approach.

Studies attempting to predict the development of severe respiratory failure in patients with a COVID-19 infection using machine learning algorithms have yielded different results due to differences in variable selection. We aimed to predict the development of severe respiratory failure, defined as the need for high-flow oxygen support, continuous positive airway pressure, or mechanical ventilation, in patients with COVID-19, using machine learning algorithms to identify the most important variables in achieving this prediction. This retrospective, cross-sectional study included COVID-19 patients with mild respiratory failure (mostly receiving oxygen through a mask or nasal cannula).

The Comparison of Low and High-Dose Scintigraphy Findings in Patients with Primary Parathyroid Lesions in which Intraoperative Gamma-Probe was Applied.

Objective: We aimed to evaluate the effectiveness of high-dose and low-dose use of radioactive material in intraoperative gamma probe application methods in patients diagnosed with primary hyperparathyroidism and planned for surgery.

Methods: 47 patients with primary hyperparathyroidism underwent minimally-invasive parathyroid surgery (MIS) after preoperative imaging studies consisting of ultrasonography (USG) and sestamibi parathyroid scintigraphy (SPS) showed a possible primary parathyroid lesion (PPL). All patients received Tc-99 sestamibi on day-of-surgery imaging (DOSI) to help with the localization of a primary parathyroid lesion (PPL) via both DOSI and intraoperative gamma probe (IGP).

Evaluation of Interstitium by Lymphatic Uptake Method in Chronic Bilateral Lower Extremity Edema.

Objective: Symmetrical bilateral lower extremity edema (BLEE) needs to be treated effectively. Finding the cause of this condition increases the success of treatment. Fluid increase in the interstitial space (FIIS) is always present as a cause or a result.

Evaluation of Dyspepsia with Optimal and Suboptimal Gastric Emptying Tests in Patients with Euthyroid Goiter.

Objective: The presence of gastroparesis in patients with dyspepsia can be evaluated by gastric emptying scintigraphy. We aimed to evaluate gastroparesis with optimal solid gastric emptying scintigraphy and suboptimal liquid gastric emptying scintigraphy in euthyroid goiter patients with dyspepsia.

Methods: We included 67 patients diagnosed with euthyroid goiter with dyspepsia complaints.

Antibacterial and antioxidant activities of traditional medicinal plants from the Erzurum region of Turkey.

Background: In this study, 13 different extracts were investigated which are grown in the region of Erzurum.

Objective: The aim of this study was to screen various plant extracts that are known and used for medicinal purposes such as Ferula communis L., Rumex patientia L.

Synthesis of somenew hybride molecules containing several azole moieties and investigation of their biological activities.

1,2,4-Triazole-3-one prepared from tryptamine was converted to the corresponding carbotioamides by several steps. Their treatment with ethyl bromoacetate or 4-chlorophenacyl bromide produced the corresponding 5-oxo-1,3-thiazolidine or 3-(4-chlorophenyl)-1,3-thiazole derivatives. Acetohydrazide derivative that was obtained starting from tryptamine, was converted to the corresponding Schiff basis and sulfonamide by the treatment with suitable aldehydes and benzensulphonyl chloride, respectively.

Syntheses and biological activities of new hybrid molecules containing different heterocyclic moieties.

4-Aryl-5-(pyridin-3-yl)-4H-1,2,4-triazole-3-(thi)oles 5-7, obtained starting from nicotinic acid hydrazide were converted to the corresponding Mannich bases 12-24 by the reaction with several heterocyclic amines in the presence of formaldehyde. The synthesis of S-alkylated compounds 8-11 was performed from the reaction of the corresponding triazol-5-thioles with various alkyl halides. The condensation of carbo(thio)amides 2-4 with 4-chlorophenacyl bromide afforded the corresponding 1,3-thia(oxa)zol-2(3H)-ylidene]pyridine-3-carbohydrazides 25-27.

Antimicrobial and antiurease activities of newly synthesized morpholine derivatives containing an azole nucleus.

2-[6-(Morpholin-4-yl)pyridin-3-ylamino]acetohydrazide () was obtained starting from 6-morpholin-4-ylpyridin-3-amine () via the formation of ester () and then converted to the corresponding Schiff bases () with the reaction with aromatic aldehydes. The carbothioamide (), obtained from the reaction of hydrazide with phenylisothiocyanate, was converted to the corresponding 1,2,4-triazole () and 1,3,4-thiadiazole () derivatives by the treatment with NaOH or HSO, respectively. The cyclocondenzation of with 4-chlorophenacyl bromide or ethyl bromoacetate produced the corresponding 1,3-thiazole () or 1,3-thiazolidine derivatives (), respectively.

Predicting malignant potential of gastrointestinal stromal tumors: Role of p16 and E2F1 expression.

Altered expression of cell cycle regulatory proteins in GISTs (gastrointestinal stromal tumors) may be the mechanism for their diversity in clinical behavior. The use of these tumorigenetic and cell proliferative proteins may provide an alternative route for follow-up and treatment. The aim of this study was to determine the prognostic relevance of the E2F1 and p16 expression in GISTs.