Adamantane-Appended 1,2,3-Triazole Hybrids: Synthesis and α-Glucosidase Inhibition Studies through Experimental and In Silico Approach.

In search of potent inhibitors of α-glucosidase, adamantane-appended 1,2,3-triazoles (4a-4f, 6a-6f, and 8a-8f) are synthesized using Click reaction. After establishing their structure using spectral studies, all the molecular hybrids are assayed for α-glucosidase inhibition. Compounds 6c (IC = 8.

A Review on Anticancer Potential and Structure-Activity Relationships (SAR) of Novel EGFR/HER2 Inhibitors.

Human Epidermal Growth Receptor (HER) plays an important role in cell signalling pathways and influences different cell functioning like angiogenesis, apoptosis, metastasis, and growth of cells. Their family includes four members with structural similarities, named EGFR/HER1, HER2, HER3, and HER4. Overexpression of these receptors is responsible for the development of cancer.

Recent Developments in Triazole Derivatives as α-Glucoside Inhibitors for the Treatment of Diabetes.

Diabetes mellitus, a serious metabolic health condition and one of the most common diseases around the globe, primarily arises due to elevated blood sugar levels and causes multiple metabolic abnormalities. Nowadays, it has become the biggest challenge for the scientific community. Serious fatal health problems, such as neuropathy, retinopathy, and nephropathy, are the result of mismanagement of this illness, which significantly lowers the quality of life.

Recent progress and structural insights of potential Hsp90 inhibitors as anticancer agents.

Hsp90, or heat shock protein 90, a well-preserved molecular chaperone that is essential for the coordination of numerous biological pathways and cellular processes. Hsp90 is a molecular chaperone, which promises a target for cancer treatment. Hsp90 inhibitors are a class of drugs that have been extensively studied in preclinical models and demonstrated promise in treating a variety of illnesses, particularly cancer.