Publications by authors named "Subash K Chaudhary"
Repurposing flavopiridol as an inhaled therapeutic for pulmonary fibrosis.
Eur J Pharmacol
August 2025
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease with limited therapeutic options. Cyclin-dependent kinase 9 (CDK9), a key transcriptional regulator, has been implicated in fibrotic diseases, but no therapies targeting CDK9 have been developed for IPF. This investigation found that CDK9 expression was significantly elevated in IPF lung fibroblasts, correlating with an enhanced fibrogenic transcriptional profile and phenotype.
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- Single crystals of organic compounds that respond to heat or light are well-studied, but those showing extreme mechanical response are less common in research.
- A tetrafluoro(aryl)sulfanylated bicyclopentane developed in this study exhibited a low-temperature thermosalient effect, where crystals jumped and disintegrated at temperatures below ∼193 K.
- Investigations using various techniques revealed that the mechanical response is not solely due to a chemical transformation or phase transition, but rather related to the release of built-up strain and possibly influenced by microstructural changes or impurities within the crystal.
Production of Inhalable Ultra-Small Particles for Delivery of Anti-Inflammation Medicine via a Table-Top Microdevice.
Micromachines (Basel)
August 2022
A table-top microdevice was introduced in this work to produce ultrasmall particles for drug delivery via inhalation. The design and operation are similar to that of spray-drying equipment used in industry, but the device itself is much smaller and more portable in size, simpler to operate and more economical. More importantly, the device enables more accurate control over particle size.
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