Publications by authors named "Steven Verloop"
The Impact of Once Daily Dosing on Protein Binding of Clozapine and Norclozapine.
Marieke M Beex-Oosterhuis
,
S F Cedric Lau
,
Charlotte van Kesteren
,
Steven Verloop
,
Koen P Grootens
J Clin Psychopharmacol
May 2025
Purpose/background: Clozapine and norclozapine are highly protein bound. Currently, clozapine is increasingly prescribed once daily (QD). Higher (once daily) doses may theoretically lead to saturation of protein binding of (nor)clozapine, resulting in increased unbound fractions.
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