Publications by authors named "Steven D Pan"
Background: Microglia initiates and sustains the inflammatory reaction that drives the pathogenesis of pneumococcal meningitis. The expression of the G-protein cannabinoid receptor type 2 (CB2) in the brain is low, but is upregulated in glial cells during infection. Its activation down-regulates pro-inflammatory processes, driving microglia towards an anti-inflammatory phenotype.
View Article and Find Full Text PDFPerformance of PROMIS Global-10 Compared With Legacy Instruments for Rotator Cuff Disease.
Am J Sports Med
January 2019
Article Synopsis
- - The PROMIS Global-10 tool was developed to evaluate physical and mental health and needs validation for specific patient groups, like those with rotator cuff issues.
- - The study involving 323 patients found strong correlation between PROMIS Global-10 and EQ-5D scores, particularly for physical assessments, but weaker for mental scores; no ceiling or floor effects were identified.
- - Although mean scores between estimated and actual EQ-5D scores were similar, there was significant variance in individual scores, suggesting that the PROMIS tool may not be as reliable for personal assessments despite overall good correlation.
Performance of PROMIS Global-10 compared with legacy instruments in patients with shoulder arthritis.
J Shoulder Elbow Surg
December 2018
Background: The Patient-Reported Outcomes Measurement Information System (PROMIS) Global-10 measures physical and mental health and provides an estimated EuroQol-5 Dimension (EQ-5D) score. The purpose of this study was to determine the correlation between the PROMIS Global-10 and several gold-standard legacy measures to validate its overall performance and usefulness in patients with shoulder arthritis.
Methods: The study prospectively enrolled 161 patients with shoulder arthritis before treatment.