Arthroscopic Anchor Placement During Shoulder Anterior Labral Repair in the Beach-Chair Versus the Lateral Decubitus Position: An Imaging Analysis.

Background: Arthroscopic shoulder capsuloligamentous repair can be performed in the beach-chair (BC) or lateral decubitus (LD) position. Patient positioning may influence anchor placement. Limited research exists evaluating these 2 positioning techniques, specifically with respect to anchor position and trajectory.

Strangulated Indirect Inguinal Hernia-Containing Bladder: A Case Report.

Inguinal hernias involving the bladder are exceedingly rare and pose a diagnostic challenge. Identifying bladder involvement within an inguinal hernia is imperative to avoid iatrogenic bladder injuries and subsequent complications. Here we discuss a case of inguinal bladder herniation and bladder visualization using methylene blue dye intraoperatively.

Current concepts: the hip, core and kinetic chain in the overhead athlete.

Background: As overhead sports continue to grow in popularity, there has been increased interest in optimizing sports performance and injury prevention in these athletes. The hip, core, and kinetic chain have become a focus of research in recent decades, and their importance in upper extremity mechanics is now being recognized.

Methods: An extensive review was carried out to identify papers correlating the hip, core and/or kinetic chain in overhead athletic performance and injury.

Patient-Derived Xenografts as an Innovative Surrogate Tumor Model for the Investigation of Health Disparities in Triple Negative Breast Cancer.

Despite a decline in overall incidence rates for cancer in the past decade, due in part to impressive advancements in both diagnosis and treatment, breast cancer (BC) remains the leading cause of cancer-related deaths in women. BC alone accounts for ∼30% of all new cancer diagnoses in women worldwide. Triple-negative BC (TNBC), defined as having no expression of the estrogen or progesterone receptors and no amplification of the HER2 receptor, is a subtype of BC that does not benefit from the use of estrogen receptor-targeting or HER2-targeting therapies.

Return to Driving After Anterior Cruciate Ligament Reconstruction: A Systematic Review.

Background: Guidelines for return to driving after anterior cruciate ligament reconstruction (ACLR) have not been established.

Purpose: To review the literature pertaining to driving after ACLR and provide evidence-based guidelines to aid clinicians in counseling patients about driving after ACLR.

Study Design: Systematic review; Level of evidence, 4.

Drug resistance profiling of a new triple negative breast cancer patient-derived xenograft model.

Background: Triple-negative breast cancer (TNBC) represents an aggressive subtype with limited therapeutic options. Experimental preclinical models that recapitulate their tumors of origin can accelerate target identification, thereby potentially improving therapeutic efficacy. Patient-derived xenografts (PDXs), due to their genomic and transcriptomic fidelity to the tumors from which they are derived, are poised to improve the preclinical testing of drug-target combinations in translational models.

A novel patient-derived xenograft model for claudin-low triple-negative breast cancer.

Background: Triple-negative breast cancer (TNBC) subtypes are clinically aggressive and cannot be treated with targeted therapeutics commonly used in other breast cancer subtypes. The claudin-low (CL) molecular subtype of TNBC has high rates of metastases, chemoresistance and recurrence. There exists an urgent need to identify novel therapeutic targets in TNBC; however, existing models utilized in target discovery research are limited.

Erythrocytosis and Polycythemia Secondary to Testosterone Replacement Therapy in the Aging Male.

Introduction: Testosterone replacement therapy (TRT) is a common treatment for hypogonadism in aging males. Men with low to low-normal levels of testosterone have documented benefit from hormone replacement. Recent meta-analyses have revealed that increases in hemoglobin (Hb) and hematocrit (Hct) are the variants most commonly encountered.

A comparison of clinical and pathologic assessments for the prediction of occult nipple involvement in nipple-sparing mastectomies.

Background: Nipple-sparing mastectomy (NSM) for both risk reduction and cancer is increasing. In the cancer setting, most studies suggest the use of both clinical and intraoperative biopsy criteria in patient selection. This study examines the use of both biopsy and clinical criteria in women undergoing total nipple-removing mastectomy.

Early-onset breast cancer in a woman with Graves' disease.

The relationship between thyroid and breast diseases has been documented, but the clinical significance of Graves' disease and breast cancer is unclear. We present a young patient with a history of Graves' disease who developed a multicentric infiltrating ductal carcinoma of the breast several months after discontinuing her treatment with propylthiouracil. Early-onset breast cancer in women without a family history of early breast cancer may be related to hyperthyroidism.

Early-onset breast disease: case of a Grave condition with a favorable prognosis.

Background: The relationship between thyroid and breast diseases has been well documented, but the clinical impact of Graves' disease on breast tissue is not clear.

Patient Findings: Twenty-seven year-old African American female patient who presented with multiple bilateral breast masses and skin thickening and ulcerations. Biopsy of the breast masses demonstrated fat necrosis.