Calcium-dependent nonlinearity describes the after-effects of different patterns of theta-burst TMS.

Objective: Optimisation of transcranial magnetic stimulation protocol parameters can potentially improve their efficacy through theoretical mathematical models. This study aims to develop an elaborate but still parsimonious quantitative model for understanding the dosage-dependency of Theta-Burst Stimulation (TBS).

Methods: We propose a calcium-dependent nonlinear model that uses Michaelis-Menten kinetics to represent competing molecular pathways in postsynaptic neurons during TBS intervention.

Rethinking noise floor characterisation in motor-evoked potentials.

. Motor-evoked potentials (MEPs) in response to brain stimulation, such as transcranial magnetic stimulation (TMS), allow quantification of corticospinal excitability and have served in the design of almost all available neuromodulatory interventions. So-called thresholding of MEPs at a point not too far above the noise floor establishes the reference point for dosage and safety.

Extraction of three mechanistically different variability and noise sources in the trial-to-trial variability of brain stimulation.

Motor-evoked potentials (MEPs) are among the few directly observable responses to external brain stimulation and serve a variety of applications, often in the form of input-output (IO) curves. Previous statistical models with two variability sources inherently consider the small MEPs at the low-side plateau as part of the neural recruitment properties. However, recent studies demonstrated that small MEP responses under resting conditions are contaminated and over-shadowed by background noise of mostly technical quality, e.

A revised calcium-dependent model of transcranial magnetic theta-burst stimulation.

Objective: Calcium dependency is presently an essential assumption in modelling the neuromodulatory effects of transcranial magnetic stimulation. Y.Z.