Publications by authors named "Stepan A Nersisyan"
Purpose: The transcription factor Fra-2 affects the invasive potential of breast cancer cells by dysregulating adhesion molecules in vitro. Previous results suggested that it upregulates the expression of E- and P-selectin ligands. Such selectin ligands are important members of the leukocyte adhesion cascade, which govern the adhesion and transmigration of cancer cells into the stroma of the host organ of metastasis.
View Article and Find Full Text PDFHIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons.
Andrey A Poloznikov
,
Stepan A Nersisyan
,
Dmitry M Hushpulian
,
Eliot H Kazakov
,
Alexander G Tonevitsky
Front Pharmacol
January 2021
Article Synopsis
- The review discusses the potential benefits and drawbacks of using HIF prolyl hydroxylase inhibitors as a treatment option for COVID-19.
- These inhibitors can enhance the production of erythropoietin (Epo), which has anti-inflammatory and healing effects, possibly helping patients with moderate to severe symptoms.
- However, while they may address complications arising from the disease, they are not expected to be effective in preventing the initial stages of COVID-19 infection.