Prognostic Impact of Mast Cell Infiltration Detected by Flow Cytometry on Excised Sentinel Lymph Nodes in Dogs With Newly Diagnosed Mast Cell Tumours.

Lymph node (LN) metastasis is a negative prognostic factor in canine mast cell tumours (MCTs). Flow cytometry (FC) can identify and quantify mast cells (MCs) in LNs. This tri-institutional prospective study aimed to evaluate the impact of previously reported MC cut-off values in sentinel LNs (SLNs) detected by FC on clinical outcomes in dogs with cutaneous or subcutaneous MCTs, and to determine a prognostically significant cut-off.

Flow Cytometry for the Detection and Quantification of Mast Cells in Lymph Nodes: A Prospective Study in 64 Dogs With Mast Cell Tumour.

Nodal metastasis is a negative prognostic factor in dogs with mast cell tumours (MCTs), thus early detection enables more informed decision-making and provides valuable prognostic information. The aim of this study is to assess the concordance between histopathologic findings of LNs and cytology and flow cytometry (FC), respectively, and to evaluate the ability of FC to differentiate between metastatic (HN2-HN3) and non-metastatic (HN0-HN1) LNs. Overall, 117 LNs from 64 dogs with first occurring MCTs were submitted for cytology, histology and FC.

Ki67 Index in Patnaik Grade 2/Kiupel Low-Grade Canine Cutaneous Mast Cell Tumors with Early Lymph Node Metastasis: A Descriptive Study.

Several studies evaluating Ki67 in canine cutaneous mast cell tumors (cMCTs) have reported its prognostic value when tumors of all histological grades are included. This study aims to evaluate whether the Ki67 index has a predictive value in a homogeneous cohort of G2/LG cMCTs with HN2 lymph nodes (LNs) and to describe the clinical outcome. The second goal was to explore the correlation between the Ki67 index and MC.

The Effect of Different Opioids on Acid-Base Balance and Blood Gas Analysis in Hospitalized Dogs.

Pain management is central to veterinary practice, contributing to successful case outcomes and enhancement of the veterinarian-client-patient relationship. Analgesic drugs represent one of the pillars of the multimodal approach to acute and chronic pain management. In dogs, the most used opioids are methadone, buprenorphine and tramadol.

Suspected Drinking Water Poisoning in a Domestic Kitten with Methemoglobinemia.

A 4-month-old male indoor cat was referred for dyspnea, mental dullness and weakness, which appeared two days earlier. The cat had been adopted at 3 months of age. Physical exam showed cyanosis, dyspnea and mild hypothermia.