Publications by authors named "Soumaya Jadoui"
The localization, origin, and impact of platelets in the tumor microenvironment are tumor type-dependent.
J Exp Clin Cancer Res
March 2024
Article Synopsis
- Scientists studied how platelets (tiny blood cells) interact with different types of tumors.
- They looked at two tumors: one from breast cancer (AT-3) and one from skin cancer (B16F1).
- They found that platelets are important in both tumors but work differently depending on the type of cancer.
Article Synopsis
- The study investigates the expression of Syndecan-1 (SDC-1), a heparan sulfate proteoglycan, in relation to thoracic aortic aneurysm (TAA) pathology.
- Human TAA specimens showed a significant increase in SDC-1 mRNA (3.6-fold) and protein (2.3 times) compared to healthy tissues, mainly expressed by smooth muscle cells.
- Despite these increases, SDC-1 does not appear to influence the progression or rupture of TAA, suggesting it could serve as a potential biomarker for the disease instead.
In recent years, accumulating evidence has indicated that platelets continuously repair vascular damage at sites of inflammation and/or infection. Studies in mouse models of inflammation have highlighted the fact that the mechanisms underlying bleeding prevention by platelets in inflamed organs can substantially differ from those supporting primary hemostasis following tail tip transection or thrombus formation in models of thrombosis. As a consequence, exploration of the hemostatic function of platelets in inflammation, as well as assessment of the risk of inflammation-induced bleeding associated with a platelet deficit and/or the use of anti-thrombotic drugs, require the use of dedicated experimental models.
View Article and Find Full Text PDF