Publications by authors named "Sophia Keddache"
Introduction: Pulmonary veno-occlusive disease (PVOD) is a rare and severe subtype of pulmonary arterial hypertension (PAH). Although European Society of Cardiology/European Respiratory Society (ESC/ERS) guidelines advise assessing PAH severity at baseline and during follow-up, no existing risk assessment methods have been validated for PVOD. This study aimed to identify prognostic factors, examine the impact of treatment strategies and evaluate risk assessment methods for PVOD patients.
View Article and Find Full Text PDFBackground: Dyspnoea is a common persistent symptom after COVID-19. Whether it is associated with functional respiratory disorders remains unclear.
Methods: We assessed the proportion and characteristics of patients with "functional respiratory complaints" (FRCs) (as defined by Nijmegen Questionnaire >22) among 177 post-COVID-19 individuals who benefited from outclinic evaluation in the COMEBAC study (, symptomatic and/or intensive care unit (ICU) survivors at 4 months).
COVID-19 in Patients with Pulmonary Hypertension: A National Prospective Cohort Study.
Am J Respir Crit Care Med
September 2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with pulmonary endothelial dysfunction. There are limited data available on the outcomes of coronavirus disease (COVID-19) in patients with pulmonary hypertension (PH), a disease characterized by pulmonary endothelial dysfunction. To describe characteristics and outcomes of patients with precapillary PH and COVID-19.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the inflammatory response in patients with chronic obstructive pulmonary disease (COPD) linked to organic dust exposure (OD-COPD) compared to those with tobacco-related COPD (T-COPD) or both.
- It evaluates the distribution of immune cells and levels of specific cytokines in blood samples, noting significant differences between groups, particularly lower NK and CD8+ T cells in OD-COPD.
- The findings suggest OD-COPD has a distinct inflammatory profile characterized by higher type 2 immunity cytokines and different responses to immune stimulation compared to T-COPD.
Background: In idiopathic pulmonary fibrosis (IPF), some physiological parameters measured during a 6-min walk test (6-MWT) impart reliable prognostic information. Sit-to-stand tests (STSTs) are field exercise tests that are easier to implement than the 6-MWT in daily practice.
Objectives: The aims of the study were to test the reproducibility and compare 2 STSTs (the 1-min STST [1-STST] and the semi-paced 3-min chair rise test [3-CRT]) in IPF, and to determine if selected physiological parameters (speed of displacement and changes in pulse oxygen saturation [SpO2]) are interchangeable between the STSTs and the 6-MWT.
Article Synopsis
- A 35-year-old man was hospitalized due to frequent pneumonia, along with two months of difficulty breathing during exertion and a persistent productive cough with thick, whitish mucus.
- Despite receiving antibiotics, his symptoms persisted, and he experienced a weight loss of 5 kg during this time.
- His medical history was mostly unremarkable apart from a 10 pack-year smoking history and he didn't have any issues with swallowing, fever, or chest pain.