Epigallocatechin Gallate in Ameliorates Skin Aging by Reducing Mitochondrial ROS Production.

Reactive oxygen species (ROS) generated by mitochondrial dysfunction damage cellular organelles and contribute to skin aging. Therefore, strategies to reduce mitochondrial ROS production are considered important for alleviating skin aging, but no effective methods have been identified. In this study, we evaluated substances utilized as cosmetic ingredients and discovered () as a substance that reduces mitochondrial ROS levels.

Identification of senescence rejuvenation mechanism of extract including honokiol as a core ingredient.

Reactive oxygen species (ROS) contribute to aging by mainly damaging cellular organelles and DNA. Although strategies to reduce ROS production have been proposed as important components of anti-aging therapy, effective mechanisms to lower ROS levels have not yet been identified. Here, we screened natural compounds frequently used as cosmetic ingredients to find substances that reduce ROS levels.

Efficacy of Dendrobium candidum polysaccharide extract as a moisturizer.

Introduction: This study investigated the role of natural polymers as moisturizers with low toxicity and biodegradability in the cosmetic and pharmaceutical industries. We isolated a polysaccharide extract from Dendrobium candidum (D. candidum) and determined its efficacy in skin hydration when used as an active cosmetic ingredient.

Effect of red ginseng NaturalGEL on skin aging.

Background: In aged skin, degradation of collagen fibers, which occupy the majority of the extracellular matrix in the dermis, and changes of aquaporin 3 (AQP3) and skin constituents, such as hyaluronic acid and ceramide, cause wrinkles and decrease skin moisturization to contribute to dryness and lower elasticity skin. Red ginseng (RG) is used as a cosmetic and food material and is known to protect from UVB-induced cell death, increase skin hydration, prevent wrinkles, and have an antioxidative effect. But, in general, RG used as a material is the soluble liquid portion in the solvent, and the part that is not soluble in the solvent is discarded.

Novel phytoceramides containing fatty acids of diverse chain lengths are better than a single C18-ceramide -stearoyl phytosphingosine to improve the physiological properties of human stratum corneum.

Ceramides in the human stratum corneum (SC) are a mixture of diverse -acylated fatty acids (FAs) with different chain lengths. C24 is the major class of FAs of ceramides. However, there are also other classes of ceramides with diverse chain lengths of FAs, and these lengths generally range from C16 to C26.