Enzyme and Thermal Dual Responsive Amphiphilic Polymer Core-Shell Nanoparticle for Doxorubicin Delivery to Cancer Cells.

Dual responsive polymer nanoscaffolds for administering anticancer drugs both at the tumor site and intracellular compartments are made for improving treatment in cancers. The present work reports the design and development of new thermo- and enzyme-responsive amphiphilic copolymer core-shell nanoparticles for doxorubicin delivery at extracellular and intracellular compartments, respectively. A hydrophobic acrylate monomer was tailor-made from 3-pentadecylphenol (PDP, a natural resource) and copolymerized with oligoethylene glycol acrylate (as a hydrophilic monomer) to make new classes of thermo and enzyme dual responsive polymeric amphiphiles.

Super LCST thermo-responsive nanoparticle assembly for ATP binding through the Hofmeister effect.

The present investigation reports the development of a super LCST thermo-responsive amphiphilic nanoparticle assembly for the detection of adenosine triphosphate (ATP) through the Hofmeister effect. For this purpose, a new diblock molecule was designed based on hydrophilic polyethylene glycol and the renewable resource 3-pendadecylphenol as the hydrophobic unit. The amphiphile self-assembled as a 150 nm micellar nanoparticle and showed a super lower critical solution temperature (LCST) above 90 °C.

Thermo-responsive and shape transformable amphiphilic scaffolds for loading and delivering anticancer drugs.

Shape transformable carriers are an important class of biomaterials for selective drug delivery in a cancer tissue physiological environment. Here, we report the first example of an in situ shape transformable thermo-responsive amphiphilic scaffold for loading and delivering anticancer drugs at the cancer tissue temperature. New amphiphiles having a hydrogen bonded amide linkage that connects hydrophilic oligoethylene glycol with the hydrophobic renewable resource 3-pendadecylphenol were tailor made through multi-step organic synthesis.

Amphiphilic diblocks sorting into multivesicular bodies and their fluorophore encapsulation capabilities.

Synthetic macromolecular diblocks sorting into mutivesicular bodies (MVBs) and their fluorophore encapsulation pathways were reported. Renewable resource based diblocks having hydrophobic units and flexible hydrophilic polyethylene glycols (PEG) were custom designed for the above purpose. Single crystal structure was resolved to prove the existence of the strong intermolecular interactions and the formation of unilamellar layer-like self-assemblies.