Genetic renaissance: a cross-regional analysis of the approval landscape of authorised gene therapeutics in paediatrics, challenges and future prospects.

Gene therapies are proven to be a milestone in the treatment of genetic disorders, especially in children who bear a disproportionately high burden of rare and hereditary diseases. Clinical evaluation of gene therapy (GT) in paediatrics is a significant challenge for every regulatory body. This study examined the available data on GT products that have been authorised for use by children in Japan, Europe, and the United States.

Unveiling Gaps and Demographic Influences in Alzheimer's Therapy: A Data-Centric Study of FDA-Approved Late-Phase Clinical Trials.

Background: Alzheimer's disease is more prevalent in women than in men. In this study, the author examined the U.S.

Chronic puerperal complete uterine inversion due to mismanaged third stage of labour.

A primipara from a rural area presented with complaints of difficulty in having coitus, continuous bleeding per vaginum and watery vaginal discharge following a history of full-term vaginal delivery 7 months back of an asphyxiated baby resulting in term neonatal death. There was a history of prolonged third stage of labour and severe postpartum haemorrhage. On per speculum examination, a congested and hyperaemic red globular mass of 5 cm × 6 cm was seen in the vagina up to the level of introitus which bled on touch.

Massive Ovarian Mucinous Cystadenoma Complicating Term Birth.

Usually, symptomatic ovarian cysts in pregnancy require surgical removal in the second trimester. However, occasionally, large ovarian cysts may be encountered in the third trimester, which might hinder normal vaginal delivery. Herein, we present one such case to highlight the challenges of managing a large ovarian cyst in a full-term pregnancy.

Understanding Adolescent Gynecological Issues: A Cross-Sectional Study at a Tertiary Care Center.

Background And Objectives: Adolescence is a crucial phase in a woman's life, as it signifies the beginning of her reproductive journey. During this time, there are notable variations in sexual development and a sense of caution that can present challenges for healthcare providers. The rationale for studying adolescent gynecological problems lies in the need to understand and address the unique reproductive health challenges faced by young girls.

Laparoscopic-assisted neo-cervico-vaginal anastomosis and neo-vagina creation in congenital atresia: A retrospective study measuring the outcome and success.

Unlabelled: Cervico-vaginal agenesis is a developmental disorder classified as a Mullerian duct anomaly.

Study Objective: We aimed to study the surgical outcomes of vaginoplasty and laparoscopic-assisted cervical-vaginoplasty carried out using our set-up from June 2016 to December 2022. Additionally, we measured the success of our modified laparoscopy-assisted neo-cervical creation.