Publications by authors named "Simone Jacoby"
Objective: Data on the impact of coronavirus disease 2019 (COVID-19) in people with HIV (PWH) are lacking in resource-constrained settings. We utilized existing randomized clinical trials (RCTs) on antiretroviral therapies (ART) in HIV-1 infection to conduct a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serosurvey, between January and March 2021, while characterizing participants' features.
Design: Cross-sectional serosurvey.
Article Synopsis
- A significant change in the availability of antiretroviral therapies has allowed researchers to assess new second-line treatments for HIV-1 in low- and middle-income countries through the DEFT trial.
- The DEFT trial, initiated in 2017, compares a standard regimen of boosted darunavir with NRTIs to a newer NRTI-sparing regimen with boosted darunavir and dolutegravir.
- Arising from recent updates in treatment guidelines, the study decided to incorporate the evaluation of the TLD regimen as a third arm, instead of starting a new trial, to optimize resources and streamline recruitment.
Unlabelled: Both HIV infection and antiretroviral therapy (ART) are associated with lower bone mineral density (BMD) and increased fracture risk. Because the relative contributions of ART and untreated HIV to BMD loss are unclear, it is important to quantify the effect of ART on bone. We compared the effect of early ART initiation (CD4 >500 cells/μL) with deferred ART on change in BMD in the START Bone Mineral Density substudy, a randomized trial evaluating the effect of immediate ART initiation versus deferring ART (to CD4 <350 cells/μL).
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