Publications by authors named "Simon Trapp"
Impact of COVID-19-adapted guidelines on resuscitation quality in out-of-hospital-cardiac-arrest: a manikin study.
Minerva Anestesiol
December 2021
Background: The aim of this study is to evaluate the effects of European Resuscitation Council (ERC) COVID-19-guidelines on resuscitation quality emphasizing advanced airway management in out-of-hospital-cardiac-arrest.
Methods: In a manikin study paramedics and emergency physicians performed advanced cardiac life support in three settings: ERC guidelines 2015 (control), COVID-19-guidelines as suggested with minimum staff (COVID-19-minimal-personnel); COVID-19-guidelines with paramedics and an emergency physician (COVID-19-advanced-airway-manager). Main outcome measures were no-flow-time, quality metrics as defined by ERC and time intervals to first chest compression, oxygen supply, intubation and first rhythm analysis.
Article Synopsis
- Mutations in the CFTR gene are linked to cystic fibrosis (CF) and chronic pancreatitis, but patients with CFTR mutations usually retain some pancreatic function compared to those with CF.
- Researchers used transgenic mice with residual CFTR function to study the severity of pancreatitis and found that while pancreatic and lung injuries were worse, the activation of trypsin and necrosis did not differ from controls at certain time points.
- The study concluded that CFTR mutations that still allow some pancreatic function can worsen experimental pancreatitis primarily by impairing duct cell function and promoting inflammation, rather than making acinar cells more vulnerable to damage.