Identifying potential drugs for treating Cardiovascular-kidney metabolic syndrome via reverse network pharmacology.

Background: Cardiovascular, Kidney and metabolic syndrome (CKM) is a complex disease, for which current therapeutic approaches have limited efficacy. This study aims to screen for potential targets and novel drugs for treating CKM using network pharmacology.

Methods: Using reverse network pharmacology, core targets and potential drugs for CKM were identified.

The association of life's essential 8 with prevalence of chronic respiratory diseases in adults: insights from NHANES 2007-2018.

Objective: Chronic respiratory diseases (CRDs) and cardiovascular diseases (CVD) share common risk factors and frequently co-occur, leading to poorer outcomes. Life's Essential 8 (LE8), a novel metric for cardiovascular health, may provide insights into this association. This study investigates the relationship between LE8 and CRDs to identify modifiable factors for targeted prevention.