Publications by authors named "Shuyin Tan"
Spinal cord injury (SCI) induces severe functional impairments and involves intricate secondary injury mechanisms. Tanshinone IIA (TIIA), a key bioactive component of Salvia miltiorrhiza, exhibits neuroprotective potential, yet its role in ferroptosis regulation post-SCI remains undefined. This study explored the protective effects and underlying mechanisms of TIIA in SCI.
View Article and Find Full Text PDFThe Genetics of 241 Fetuses With Talipes Equinovarus: A 8-Year Monocentric Retrospective Study.
Mol Genet Genomic Med
February 2025
Objective: This study aims to investigate the utility of chromosomal microarray analysis (CMA) and whole exome sequencing (WES) in fetuses diagnosed with talipes equinovarus (TE), as well as to explore the genetic factors contributing to TE.
Methods: The study reviewed a total of 241 fetuses with TE between January 2015 and December 2023, categorizing them into two groups based on the absence or presence of additional ultrasound anomalies: 163 cases (67.6%) in the isolated TE group and 78 cases (32.
Background: Malformations of cortical development (MCD) are a group of congenital disorders characterized by structural abnormalities in the brain cortex. The clinical manifestations include refractory epilepsy, mental retardation, and cognitive impairment. Genetic factors play a key role in the etiology of MCD.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on a rare condition known as Infantile-onset ascending hereditary spastic paralysis (IAHSP) caused by ALS2 gene mutations, investigating two affected Chinese siblings.
- Researchers used whole-exome sequencing to identify a novel variant in the ALS2 gene and performed various analyses to understand its effects on the genetic and clinical presentation of the disorder.
- Findings highlight the importance of genetic testing, such as whole-exome sequencing, in diagnosing IAHSP, which can be challenging based on symptoms alone, and supports broader screening for ALS2 variants.
Study on the correlation between the ultrasound phenotype and copy number variation of abnormal embryo in spontaneous abortion.
J Obstet Gynaecol Res
November 2021
Objective: This study aimed to explore the correlation between the ultrasound phenotype and copy number variation (CNV) of abnormal embryos in spontaneous abortion by investigating the abnormal chromosome copy number of embryos at different developmental stages in early spontaneous abortion.
Methods: A total of 539 patients who had early spontaneous abortion in our hospital between 2015 and 2019 were divided into seven groups according to the phenotype of abnormal embryonic development during pregnancy, and the embryonic tissues of the patients were subjected by single nucleotide polymorphism (SNP) microarray.
Results: Among 377 cases with abnormal CNV, 295 (78.
Non-immune hydrops fetalis (NIHF) is a complex condition with a high mortality and morbidity rate. Here we report the etiology and outcome of 1004 fetuses with NIHF, in a large single Maternal and Children's hospital of Southern China, since the year of 2009 to 2016. Among these 1004 fetuses with NIHF, the etiology was identified prenatally in 722 of them (72%).
View Article and Find Full Text PDFObjective: To evaluate the predictive value of three-dimensional (3D)-power Doppler sonography on recurrent miscarriage.
Materials And Methods: The study patients were divided into a recurrent miscarriage group (30 cases) and a normal pregnancy group (21 cases). Measurement of endometrial thickness was performed using two-dimensional transvaginal ultrasound in the midluteal phase.