Liquiritigenin Alleviates Inflammation and Mitochondrial Dysfunction in Acute Pancreatitis via ERβ-VDAC1 Signaling.

Ethnopharmacological Relevance: Liquorice (Gancao), a classic Chinese herb, has been historically prescribed for inflammation and gastrointestinal disorders. Its bioactive flavonoid liquiritigenin (4',7-dihydroxyflavone) exhibits anti-inflammatory properties, yet its efficacy against acute pancreatitis (AP) remains unexplored.

Aim: To systematically investigate the therapeutic potential of liquiritigenin against AP and decipher its estrogen receptor beta (ERβ)-mediated mitochondrial regulatory mechanisms.

Real-time obstructive sleep apnea detection from frequency analysis of EDR and HRV using Lomb Periodogram.

In this study, an effective real-time obstructive sleep apnea (OSA) detection method from frequency analysis of ECG-derived respiratory (EDR) and heart rate variability (HRV) is proposed. Compared to traditional Polysomnography (PSG) which needs several physiological signals measured from patients, the proposed OSA detection method just only use ECG signals to determine the time interval of OSA. In order to be feasible to be implemented in hardware to achieve the real-time detection and portable application, the simplified Lomb Periodogram is utilized to perform the frequency analysis of EDR and HRV in this study.