Outcomes of Teenage Donor Hearts Transplanted into Adult Heart Transplant Recipients: A UNOS Analysis.

Objective: The safety of utilizing teenage donor hearts for adult recipients is unclear. Moreover, the appropriateness of predicted heart mass ratio (PHMr) as a size metric for teenage donors is unknown.

Methods: We used the United Network for Organ Sharing (UNOS) database to perform a retrospective analysis of heart-only adult transplant recipients (>18 years).

Understanding preservation time thresholds in the modern era of heart transplantation.

A 4-h preservation time threshold for cardiac allografts is the current standard in heart transplantation, but novel technologies are proposed to decrease the morbidity associated with prolonged allograft storage. This study examined adult heart transplant recipients from 2000-2015 and 2020-2023 in the United States, stratified into an early (2000-2015) and modern era (2020-2023), then into standard (≤ 4 h) and prolonged (≥ 5 h) preservation time groups within each era. This study reinforced the 4-h threshold in the early era, where prolonged preservation significantly increased one-year mortality (HR 1.