Publications by authors named "Shirin Ansariashlaghi"
Article Synopsis
- This study focuses on creating and testing new phenylthiosemicarbazide-phenoxy-1,2,3-triazole-N-phenylacetamide compounds (7a-l) as potential treatments for type 2 diabetes by inhibiting two key enzymes: α-glucosidase and protein tyrosine phosphatase 1-B (PTP-1B).
- All tested compounds (7a-l) showed stronger inhibition of α-glucosidase compared to acarbose, a standard drug, while only some (7a, 7g, 7h, and 7i) outperformed suramin against PTP-1B.
- The most effective inhibitors identified were compound 7i for
α-Haloenals, especially, α-bromoenals considered as one of the important building blocks in organic synthesis. They can participate in various (3+2)-, (3+3)-, (3+4)-, and (2+4)-annulation reactions with other organic molecules in the presence of an NHC catalyst to produce enantioenriched carbo-, and heterocyclic compounds. Herein, we have described NHC-catalyzed enantioselective transformations of α-bromoenals in the synthesis of various heterocycles, and carbocycles, as well as acyclic organic compounds.
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