IL-6 amplifies corneal transplant alloimmunity by inducing dysfunctional IFN-γ- secreting Treg through the VEGFA-VEGFR1 axis.

Background: Corneal allografts generally exhibit high acceptance due to the immune-privileged ocular microenvironment. Regulatory T cells (Treg) promote graft tolerance; however, in a vascularized milieu, they may acquire a pro-inflammatory phenotype. We investigated how dysfunctional Treg contribute to graft rejection through the VEGFA-VEGFR1 axis.

Treatment of nitrogen mustard-induced corneal injury with alpha-melanocyte stimulating hormone.

Nitrogen mustard (NM) exposure leads to severe corneal damage, resulting in persistent corneal inflammation, epithelial damage, endothelial dysfunction, and vision impairment. Effective therapeutic strategies to mitigate these effects remain limited. This study evaluates the protective effects of alpha-melanocyte-stimulating hormone (α-MSH) in a murine model of NM-induced corneal injury.

FericipXT-coated PEGylated rutile TiO nanoparticles in drug delivery: assessment of imatinib release.

This study presents a facile synthesis strategy for magnetic field-responsive PEGylated iron-supplement-coated rutile titanium dioxide (TiO) nanoparticles (NPs) for stimulus-responsive drug delivery. Imatinib, an anticancer drug, was successfully loaded into NPs, and its release was investigated under different pH conditions. XRD analysis confirmed the successful synthesis of PEGylated iron supplement-coated rutile titania NPs.

Synthesizing and Optimizing Rutile TiO Nanoparticles for Magnetically Guided Drug Delivery.

Introduction: Titanium dioxide nanoparticles (TiO NPs) have shown tremendous potential in targeted drug-delivery applications. Among various mechanisms, magnetically guided transport of drugs is one such technique for the said purpose. TiO NPs being diamagnetic or sometimes exhibiting very weak ferromagnetism can be modified by treating them with suitable magnetic materials.

Rapid green-synthesis of TiO nanoparticles for therapeutic applications.

Nanoparticles (NPs) with sizes ranging from 2 nm to 1 μm find various applications in the field of theranostics. Moreover, if eco-friendly methods are opted for the synthesis of biocompatible and less toxic NPs, then that's a huge success. Titanium dioxide nanoparticles (TiO NPs) have been vigorously studied for their use in medical implants, photodynamic therapy, drug delivery, biosensing and as antimicrobial agents.

In-vitro pH-responsive release of imatinib from iron-supplement coated anatase TiO nanoparticles.

Targeted drug delivery is one such precision method of delivering medication inside the human body which can vanquish all the limitations of the conventional chemotherapeutic techniques. In the present study, two types of nanoparticles (NPs) were chosen for the in-vitro pH-responsive release study of the drug, Imatinib, namely anatase Titanium Dioxide nanoparticles (TiO NPs) and iron-capped TiO NPs, designated as Fe@TiO NPs. The novelty of this work lies behind the use of commercially available iron supplement 'Autrin' meant for human consumption, as the material to coat the TiO NPs to synthesize Fe@TiO NPs.