Publications by authors named "Shi-Ping Lu"
There is currently no established systematic explanation of the clinical application and diagnostic value of insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) in breast cancer. This study utilized immunohistochemistry (IHC) to assess the expression of the IGF2BP3 protein in 299 cases of breast cancer tissues, with the aim of investigating the clinical and diagnostic significance of IGF2BP3 in breast cancer. Our results showed that the positivity rate of IGF2BP3 in breast cancer tissues was 11.
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- Excessive formation of macrophage extracellular traps (METs) has been linked to autoimmune diseases, but their role in Type 1 Diabetes (T1D) is not well understood.
- The study highlights the importance of the enzyme peptidyl arginine deiminase 4 (PAD4) in promoting METs and pro-inflammatory M1 macrophages, which exacerbates intestinal inflammation in non-obese diabetic (NOD) mice.
- Inhibition of METs formation could be a potential therapeutic strategy for T1D, as it affects the migration of pro-inflammatory T cells from the intestine to the pancreas.
Although some studies have reported on the expression and clinical significance of Fascin-1 (FSCN1) in liver cancer, the clinical application and differential diagnosis value of FSCN1 in liver cancer are still unclear. The aim of this study was to analyze the expression level of FSCN1 protein in liver cancer tissues and explore its diagnostic and application value in differentiating between hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). The immunehistochemical analysis was used to detect the expression of FSCN1 in 108 cases of HCC, 26 cases of ICC, 23 cases of liver cirrhosis, and 11 cases of normal liver tissues.
View Article and Find Full Text PDFStudy on the thermal behaviour of spontaneous combustion of open-pit minerals.
Sci Total Environ
June 2024
Article Synopsis
- The study investigates the thermal behavior of mixed slag (coal, oil shale, and coal gangue) during spontaneous combustion in an open-pit coal mine using specific thermal analysis techniques.
- Findings show that thermophysical parameters change significantly with temperature and can be categorized into five distinct stages of heat flow during heating.
- The research highlights that mixed slag exhibits unique exothermic properties compared to single minerals, which is crucial for understanding and preventing potential environmental issues from slag combustion.
Relevance and mechanism of STAT3/miR-221-3p/Fascin-1 axis in EGFR TKI resistance of triple-negative breast cancer.
Mol Cell Biochem
November 2024
The epidermal growth factor receptor 1 (EGFR) plays a crucial role in the progression of various malignant tumors and is considered a potential target for treating triple-negative breast cancer (TNBC). However, the effectiveness of representative tyrosine kinase inhibitors (TKIs) used in EGFR-targeted therapy is limited in TNBC patients. In our study, we observed that the TNBC cell lines MDA-MB-231 and MDA-MB-468 exhibited resistance to Gefitinib.
View Article and Find Full Text PDFAbnormal chromatin remodeling caused by ARID1A deletion leads to malformation of the dentate gyrus.
Cell Death Differ
September 2023
ARID1A, an SWI/SNF chromatin-remodeling gene, is commonly mutated in cancer and hypothesized to be a tumor suppressor. Recently, loss-of-function of ARID1A gene has been shown to cause intellectual disability. Here we generate Arid1a conditional knockout mice and investigate Arid1a function in the hippocampus.
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- Omega-3 polyunsaturated fatty acids (N3PUFA), like EPA and DHA, integrate into cell membranes and enhance cardiovascular health by improving endothelial function, reducing clotting issues, and lowering inflammation and oxidative stress.* -
- These fatty acids serve as precursors for bioactive lipid mediators that contribute to their positive cardiovascular effects, with studies indicating a clear relationship between higher intake and lower risk of blood clotting problems.* -
- Due to their strong safety profile, N3PUFAs are considered a potential supplement for individuals at increased risk of heart issues, particularly in the context of COVID-19, and the review discusses the ideal forms and dosages for consumption.*
The spontaneous combustion of underground minerals causes huge property losses and ecological damage. Coal and oil shale are co-associated minerals in the Fushun West Mine, and both have the ability to undergo oxidative spontaneous combustion. To study the effect of microstructure changes on the macroscopic gas product concentration during the mineral oxidation spontaneous combustion process in the Fushun West Mine, this study used a high-temperature temperature-programmed test to obtain the change trend of gas product concentration in different oxidation stages of minerals.
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- Type 1 diabetes mellitus (T1DM) is an autoimmune disease where the immune system attacks insulin-producing cells, leading to a lack of insulin.
- This study explores the use of a safe bacteria, Lactococcus lactis, to deliver specific proteins (HSP65-6IA2P2) to the gut as a treatment method for T1DM.
- Results show that this oral treatment can prevent high blood sugar levels and improve immune responses in diabetic mice, suggesting that it could be an effective strategy for T1DM prevention.