Publications by authors named "Shi-Da Lin"
Ventral posteromedial nucleus of the thalamus gates the spread of trigeminal neuropathic pain.
J Headache Pain
August 2024
Background: Widespread neuropathic pain usually affects a wide range of body areas and inflicts huge suffering on patients. However, little is known about how it happens and effective therapeutic interventions are lacking.
Methods: Widespread neuropathic pain was induced by partial infraorbital nerve transection (p-IONX) and evaluated by measuring nociceptive thresholds.
Article Synopsis
- The study investigates the role of glutamatergic neurons in the secondary somatosensory cortex (SII) in pain modulation and neuropathic pain, revealing their response to sensory inputs and their effects on nociceptive sensitivity.
- Optical manipulation of these neurons demonstrated that inhibiting them reduces pain sensitivity while activating them increases it, without impacting mood.
- The findings suggest that SII glutamatergic neurons and their connections to thalamic nuclei are involved in pain modulation and could be targeted for therapeutic interventions in neuropathic pain.
[Toxicity Testing Organisms for Marine Ecotoxicological Research in China].
Huan Jing Ke Xue
November 2022
Since the late 1970s, marine ecotoxicology began to sprout and develop in China. Based on the principles of dose-response relationships, some marine organisms are used in toxicity tests to evaluate the impact of marine pollutants on marine organisms and marine ecosystems. At the early stage, marine ecotoxicological research mainly focused on the bioaccumulation, biomagnification, and biodegradation of traditional pollutants such as heavy metals, radioactive elements, organotin, petroleum hydrocarbons, and pesticides, as well as their toxic effects on survival, growth, and other physiological indicators.
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- The study explores the connection between neuroinflammation and mood disorders related to neuropathic pain, focusing on the role of the proinflammatory cytokine HMGB1 in the medial prefrontal cortex (mPFC).
- Mice were used to model neuropathic pain and assess anxiety-like behaviors, showing that increased HMGB1 levels in the mPFC correlated with onset of anxiety symptoms earlier in neuropathic pain induced by one method compared to another.
- Targeting HMGB1 with monoclonal antibodies reduced anxiety without affecting pain perception, suggesting a potential therapeutic approach for managing mood disorders linked to neuropathic pain.
Dissecting the Neural Circuitry for Pain Modulation and Chronic Pain: Insights from Optogenetics.
Neurosci Bull
April 2022
Pain is an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage. The processing of pain involves complicated modulation at the levels of the periphery, spinal cord, and brain. The pathogenesis of chronic pain is still not fully understood, which makes the clinical treatment challenging.
View Article and Find Full Text PDFRole of tumor metastasis suppressor gene KAI1 in digestive tract carcinomas and cancer cells.
Cell Tissue Res
November 2003
The KAI1 gene is identified as a tumor metastasis suppressor gene in many types of cancer. We examined KAI1 gene and its protein KAI1/CD82 expression by in situ hybridization and immunohistochemical analysis, and found that KAI1 mRNA and protein expression were inversely correlated with lymph node and distant metastasis in digestive tract carcinomas, but not with age and gender of the patient, or with tumor differentiation. Moreover, KAI1/CD82 protein expression positively reflected the survival outcome of patients.
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