Publications by authors named "Sheikh Muhammad Ekramullah"
Article Synopsis
- The study explores how arsenic exposure in parents, particularly fathers, may affect DNA methylation in infants with spina bifida, suggesting a link between environmental toxins and genetic changes.
- Researchers analyzed arsenic levels in fathers' toenails and measured DNA methylation in various tissues from infants, finding a significant association in dural tissue.
- The findings highlight the relevance of these epigenetic changes, particularly in pathways related to neural development, and underscore the need for further research on paternal exposure to toxins.
Article Synopsis
- Spina bifida is a neural tube defect linked to genetic and environmental factors, specifically maternal arsenic exposure, which affects fetal development during pregnancy.
- The study analyzed data from 262 mothers and 220 infants in Bangladesh to explore the relationship between maternal arsenic levels and spina bifida risk, focusing on specific genetic variations in folate and arsenic metabolism.
- Results indicated that certain single-nucleotide polymorphisms (SNPs) related to arsenic metabolism in infants and mothers significantly increased the likelihood of spina bifida when combined with high arsenic exposure.
Background: Spina bifida, a developmental malformation of the spinal cord, is associated with high rates of mortality and disability. Although folic acid-based preventive strategies have been successful in reducing rates of spina bifida, some areas continue to be at higher risk because of chemical exposures. Bangladesh has high arsenic exposures through contaminated drinking water and high rates of spina bifida.
View Article and Find Full Text PDFObjective: Reports on the management and survival of children with myelomeningocele defects in Bangladesh are limited. This study describes the characteristics and outcomes of these children, focusing on the timing of surgical repair and factors affecting survival.
Methods: We enrolled patients with myelomeningoceles in a case-control study on arsenic exposure and spina bifida in Bangladesh.
Article Synopsis
- The study explored genetic factors linked to spina bifida, a severe birth defect, by analyzing DNA samples from families in Bangladesh between 2016 and 2022.
- Researchers identified three new genetic variants associated with spina bifida through advanced genetic analysis, even though they didn't find any widespread significant variants between cases and controls.
- The findings suggest these novel genetic markers could provide insights into prevention strategies, but further research with larger sample sizes is necessary to confirm the results.
Background: Spina bifida, a developmental malformation of the spinal cord, is associated with high rates of mortality and disability. Although folic acid-based preventive strategies have been successful in reducing rates of spina bifida, some areas continue to be at higher risk because of chemical exposures. Bangladesh has high arsenic exposures through contaminated drinking water and high rates of spina bifida.
View Article and Find Full Text PDFEMR adoption in Dhaka, Bangladesh: a template to index pediatric central nervous system tumor care and a review of preliminary neuro-oncologic observations.
Childs Nerv Syst
August 2022
Purpose: To describe the design, implementation, and adoption of a simplified electronic medical record (EMR) and its use in documenting pediatric central nervous system (CNS) tumors at a tertiary care referral hospital in South-East Asia.
Methods: A novel EMR, cataloguing pediatric CNS tumors was used to collect data from August 2017 to March 2020 at National Institute of Neurosciences and Hospital (NINS&H) in Dhaka, Bangladesh.
Results: Two hundred forty-nine pediatric patients with a CNS tumor were admitted to NINS&H.
Background: Arsenic exposure has been associated with gestational diabetes mellitus. However, the extent to which arsenic exposure during pregnancy is associated with postpartum glucose intolerance is unknown.
Methods: We studied 323 women in Bangladesh.
Background: Neural tube defects are a pressing public health concern despite advances in prevention from folic acid-based strategies. Numerous chemicals, in particular arsenic, have been associated with neural tube defects in animal models and could influence risk in humans.
Objectives: We investigated the relationship between parental exposure to arsenic and 17 metals and risk of neural tube defects (myelomeningocele and meningocele) in a case control study in Bangladesh.