Impact of ambient air pollution exposure during pregnancy on adverse birth outcomes: generalized structural equation modeling approach.

Background: Air pollution and several prenatal factors, such as socio-demographic, behavioural, physical activity and clinical factors influence adverse birth outcomes. The study aimed to investigate the impact of ambient air pollution exposure during pregnancy adjusting prenatal risk factors on adverse birth outcomes among pregnant women in MACE birth cohort.

Methods: Data for the study was obtained from the Mother and Child in the Environment (MACE) birth cohort study in Durban, South Africa from 2013 to 2017.

A hybrid air pollution / land use regression model for predicting air pollution concentrations in Durban, South Africa.

The objective of this paper was to incorporate source-meteorological interaction information from two commonly employed atmospheric dispersion models into the land use regression technique for predicting ambient nitrogen dioxide (NO), sulphur dioxide (SO), and particulate matter (PM). The study was undertaken across two regions in Durban, South Africa, one with a high industrial profile and a nearby harbour, and the other with a primarily commercial and residential profile. Multiple hybrid models were developed by integrating air pollution dispersion modelling predictions for source specific NO, SO, and PM concentrations into LUR models following the European Study of Cohorts for Air Pollution Effects (ESCAPE) methodology to characterise exposure, in Durban.

Harbor and Intra-City Drivers of Air Pollution: Findings from a Land Use Regression Model, Durban, South Africa.

Multiple land use regression models (LUR) were developed for different air pollutants to characterize exposure, in the Durban metropolitan area, South Africa. Based on the European Study of Cohorts for Air Pollution Effects (ESCAPE) methodology, concentrations of particulate matter (PM and PM), sulphur dioxide (SO), and nitrogen dioxide (NO) were measured over a 1-year period, at 41 sites, with Ogawa Badges and 21 sites with PM Monitors. Sampling was undertaken in two regions of the city of Durban, South Africa, one with high levels of heavy industry as well as a harbor, and the other small-scale business activity.

The spatial modification of the non-linear effects of ambient oxides of nitrogen during pregnancy on birthweight in a South African birth cohort.

Birthweight is strongly associated with infant mortality and is a major determinant of infant survival. Several factors such as maternal, environmental, clinical, and social factors influence birthweight, and these vary geographically, including across low, middle, and economically advanced countries. The aim of the study was to investigate the geographical modification of the effect of oxides of nitrogen exposure on birthweight adjusted for clinical and socio-demographic factors.

Informal-sector occupational hazards: an observational workplace assessment of the traditional medicine trade in South Africa.

Informal traditional medicine markets are trading and processing hubs for a range of plant, animal and mineral materials; however, little is known regarding the occupational risks associated with the processing and handling of these products. The aim of this study was to identify the workplace hazards of the traditional medicine trade. A walk-through observation of the workplace was conducted by two independent observers with formal training in workplace risk evaluation.

HIV induced nitric oxide and lipid peroxidation, influences neonatal birthweight in a South African population.

HIV has been implicated in adverse birth outcomes, due to increased oxidative stress and inflammation. In addition, HIV has been reported to increase nitric oxide levels. Therefore the combined exposures to HIV and traffic-related air pollution, within South Durban, South Africa (SA), may lead to adverse birth outcomes.

OGG1 Ser326Cys polymorphism, HIV, obesity and air pollution exposure influences adverse birth outcome susceptibility, within South African Women.

The global HIV and obesity epidemics are major public health concerns; particularly as both are associated with increased risk of adverse birth outcomes. Despite extensive research, their combined effect, in terms of birth outcomes, has not been investigated. A single-nucleotide polymorphism (SNP) within 8-oxoguanine glycosylase 1 (OGG1) (Ser326Cys) has been suggested to affect body mass indices and therefore could predispose South African (SA) women to adverse effects of obesity.

The Effect of Nitric Oxide Pollution on Oxidative Stress in Pregnant Women Living in Durban, South Africa.

The purpose of the study was to evaluate the effect nitric oxide (NO ) pollution had on maternal serum 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-OHdG) levels and neonatal outcomes in pregnant women living in Durban, South Africa (SA). Women, in their third trimester with singleton pregnancies, were recruited from the heavily industrialised south (n = 225) and less industrialised north (n = 152). Biomarker levels of serum 8-OHdG concentrations were analysed, and the women were genotyped for glutathione-S-transferases pi 1 (GSTP1) and glutathione-S-transferases mu 1 (GSTM1) polymorphisms.

Land use regression modelling estimating nitrogen oxides exposure in industrial south Durban, South Africa.

Background: The South Durban (SD) area of Durban, South Africa, has a history of air pollution issues due to the juxtaposition of low-income communities with industrial areas. This study used measurements of oxides of nitrogen (NO) to develop a land use regression (LUR) model to explain the spatial variation of air pollution concentrations in this area.

Methods: Ambient NO was measured over two two-week sampling periods at 32 sites using Ogawa badges.