PyBootNet: a python package for bootstrapping and network construction.

Background: Network analysis has emerged as a tool for investigating interactions among species in a community, interactions among genes or proteins within cells, or interactions across different types of data (, genes and metabolites). Two aspects of networks that are difficult to assess are the statistical robustness of the network and whether networks from two different biological systems or experimental conditions differ.

Methods: PyBootNet is a user-friendly Python package that integrates bootstrapping analysis and correlation network construction.

Genetic hypogonadal (Gnrh1) mouse model uncovers influence of reproductive axis on maturation of the gut microbiome during puberty.

The gut microbiome plays a key role in human health and gut dysbiosis is linked to many sex-specific diseases including autoimmune, metabolic, and neurological disorders. Activation of the hypothalamic-pituitary-gonadal (HPG) axis during puberty leads to sexual maturation and development of sex differences through the action of gonadal sex steroids. While the gut microbiome also undergoes sex differentiation, the mechanisms involved remain poorly understood.