WELPSA: A Green Catalyst Mediated Microwave Assisted Efficient Synthesis of Novel 5-Aminopyrazole-4-Carbonitrile Derivatives as Anticancer Agents (MCF-7, A-549) and In Silico Studies.

Malononitrile, modified hydrazine, and quinoline aldehyde were combined in a one-pot reaction under microwave irradiation to create the medicinally significant family of heterocyclic scaffolds, quinoline, coumarin, thiazole, and pyrazole 4-carbonitrile derivatives with the help of green solvent as water. WELPSA (water extract of lemon peel-soaked ash) is used to speed up the reaction in a solvent-free environment, according to more environmentally friendly reaction protocols. This methodology offers several advantages like short reaction duration, green solvent synthesis, high yield, no need for chromatographic techniques, catalyst recyclability of up to five cycles, and so on.