3D-printed scaffold with biomimetic gradient structure for promoting bone regeneration through inhibiting inflammation and facilitating in-situ biomineralization.

Critical-sized bone defects caused by trauma, congenital malformation, or tumor resection remain a major challenge around the world. Current bone tissue-engineering scaffolds are partially confined by inadequate scaffold architecture design that mismatches with natural bone tissue, which affect normal biological functions like inflammation modulation and biomineralization, thus impairing bone regeneration process. Herein, a biomimetic 3D-printed BMGP scaffold composed of polydopamine (PDA)-polylactide (PLA) scaffold and black phosphorus (BP) nanosheets/manganese carbonyl (MnCO) nanosheets/gelatin methacryloyl hydrogel (named as BMG hydrogel) was developed for augmenting bone regeneration via strengthening anti-inflammatory effect and promoting in-situ biomineralization process.

Formulation and characterization of surfactants with antibacterial and corrosion-inhibiting properties for enhancing shale gas drainage and production.

A Gemini cationic surfactant was synthesized through an aldehyde-amine condensation reaction to address challenges related to bacterial corrosion and foaming during shale gas extraction. This treatment agent exhibits sterilization, corrosion mitigation, and foaming properties. The mechanism of action was characterized through tests measuring surface tension, particle size, sterilization efficacy, corrosion mitigation efficiency, and foaming behavior.

Predictive factors for cerebrocardiac syndrome in patients with severe traumatic brain injury: a retrospective cohort study.

Background And Objective: Cerebrocardiac syndrome (CCS) is a severe complication of severe traumatic brain injury (sTBI) that carries high mortality and disability rates. Early identification of CCS poses a significant clinical challenge. The main objective of this study was to investigate potential risk factors associated with the development of secondary CCS in patients with sTBI.