The genome sequence of the zebra danio, (Hamilton, 1822) (Cypriniformes: Danionidae).

We present a genome assembly from a specimen of (zebra danio; Chordata; Actinopteri; Cypriniformes; Danionidae). The genome sequence has a total length of 1 413.66 megabases.

A predictive quality assurance model for patient-specific gamma passing rate of hyperarc-based stereotactic radiotherapy and radiosurgery of brain metastases.

Objective: Measurement-based patient specific quality assurance (PSQA) is an increasingly debated topic among medical physicists. Developments like online adaptive radiotherapy and same-day stereotactic treatments limit the time to do measurement-based PSQA. Herein, we develop a predictive machine learning model to supplement PSQA by predicting the gamma passing rate (GPR) per stereotactic arc.

Oatk: a de novo assembly tool for complex plant organelle genomes.

Plant organelle genomes, particularly large mitochondrial genomes with complex repeats, present significant challenges for assembly. The advent of long-read sequencing enables the assembly of complete genomes, but problems of resolving alternative structures remain. Here we introduce a novel tool that employs a syncmer-based assembler for rapid assembly graph construction, integrates a profile-HMM database for robust organelle identification, and leverages a new search method to find the best supported path through the assembly graph.

Custom knowledge-based planning method to escalate tumor dose for stereotactic recurrent head and neck cancer with HyperArc delivery.

Demonstrating the feasibility of dose escalation for stereotactic recurrent head and neck (RHN) cancers with a HyperArc-based RapidPlan (HARP) model using custom Simultaneous Integrated Boost Injector (SIBI) through Eclipse Scripting API (ESAPI) to facilitate automated treatment planning. Five previously treated RHN patients prescribed 30 to 35 Gy in 3 or 5 fractions, four single-lesion and one two-lesion, were retrospectively replanned with HyperArc geometry on a TrueBeam LINAC (6MV-FFF) using a HARP model with SIBI to escalate tumor dose. Escalation was achieved through the GTV and a central hotspot optimization structure being pushed toward 130% and 140% the prescription dose, respectively.

Genomics of Neotropical biodiversity indicators: Two butterfly radiations with rampant chromosomal rearrangements and hybridization.

A central question in evolutionary biology is what drives the diversification of lineages. Rapid, recent radiations are ideal systems for this question because they still show key morphological and ecological adaptations associated with speciation. While most research on recent radiations focuses on those occurring in insular environments, less attention has been given to continental radiations with complex species interactions.

Reporting Clinical Results of EPID-Based Patient-Specific Quality Assurance for Brain Stereotactic Radiosurgery/Radiation Therapy: Demonstrating the Feasibility of Same-Day Stereotactic Radiosurgery via HyperArc Delivery.

Purpose: Patient-specific quality assurance (PSQA) of complex volumetric modulated arc therapy plans via Electronic portal imaging device (EPID)-based portal dosimetry (PD) is widely adopted by the radiation therapy community. We report our EPID-based PSQA results for brain HyperArc stereotactic radiosurgery/radiation therapy (SRS/SRT) patients, justifying its efficiency for the potential of same-day LINAC-based radiosurgery.

Methods And Materials: A total of 130 brain SRS/SRT patients were treated via highly conformal HyperArc delivery for 1, 3, and 5 fractions of 18-24 Gy, 24-27 Gy, and 30-35 Gy to each lesion in either single-isocenter/single-lesion (SISL, 60 plans) or single-isocenter/multilesion (SIML, 70 plans) setting following the Alliance brain SRS/SRT clinical trial criteria.

A rare variant in associated with depression in a Mennonite pedigree causes habenula hyperactivity and stress sensitivity in mice.

Major depressive disorder (MDD) is a leading cause of disability worldwide. Risk for MDD is heritable, and the genetic structure of founder populations enables investigation of rare susceptibility alleles with large effect. In an extended Old Order Mennonite family cohort, we identified a rare missense variant in (c.

An investigation into the feasibility and efficacy of stereotactic radiosurgery for 1-3 cm single brain lesions on the ring-mounted Halcyon LINAC.

Purpose: An evaluation of the accuracy, safety, and efficiency of the Halcyon ring delivery system (RDS) for stereotactic radiosurgery (SRS) treatment to relatively small (1-3 cm) brain lesions.

Methods: After completing the extensive in-house quality assurance checks including Winston-Lutz test and independent dose verification via MD Anderson IROC SRS head phantom irradiation on Halcyon, fifteen brain SRS patients previously treated with a single dose of 20 Gy on TrueBeam (6MV-FFF) with HyperArc geometry were retrospectively replanned on Halcyon (6MV-FFF). Plan quality metrics including conformity index (CI), gradient index (GI), gradient distance (GD), PTV coverage, gross tumor volume (GTV) dose, heterogeneity index (HI), and doses to organs-at-risk (OAR) including normal brain dose were evaluated.

Development and clinical implementation of a comprehensive multifractionation scheme HyperArc-based RapidPlan model for single and multiple brain metastases.

Propose a solution to help mitigate the 1 to 2-week delay from simulation to treatment time for single-isocenter single- and multi-lesion brain stereotactic radiosurgery/radiotherapy (SRS/SRT) plans. Utilizing new machine learning techniques to automate and standardize the treatment planning process. 89 previously treated high-quality, highly conformal HyperArc SRS/SRT plans delivered on a TrueBeam LINAC (6MV-FFF), were used to develop a HyperArc-based RapidPlan (HARP) model.

A chromosomal reference genome sequence for the northern house mosquito, form , Linnaeus, 1758.

We present a genome assembly from an individual female sensu stricto (the northern house mosquito; Arthropoda; Insecta; Diptera; Culicidae), from a wild population in Sweden. The genome sequence is 533 megabases in span. Most of the assembly is scaffolded into three chromosomal pseudomolecules.

A knowledge-based planning model to identify fraction-reduction opportunities in brain stereotactic radiotherapy.

Objective: To develop and validate a HyperArc-based RapidPlan (HARP) model for three-fraction brain stereotactic radiotherapy (SRT) plans to then use to replan previously treated five-fraction SRT plans. Demonstrating the possibility of reducing the number of fractions while achieving acceptable organs-at-risk (OAR) doses with improved target biological effective dose (BED) to brain lesions.

Methods: Thirty-nine high-quality clinical three-fraction HyperArc brain SRT plans (24-27 Gy) were used to train the HARP model, with a separate 10 plans used to validate its effectiveness.

A chromosomal reference genome sequence for the malaria mosquito, , Giles, 1902.

We present a genome assembly from an individual female (the malaria mosquito; Arthropoda; Insecta; Diptera; Culicidae). The genome sequence is 224 megabases in span. Most of the assembly is scaffolded into three chromosomal pseudomolecules with the X sex chromosome assembled.

The Sensory Shark: High-quality Morphological, Genomic and Transcriptomic Data for the Small-spotted Catshark Scyliorhinus Canicula Reveal the Molecular Bases of Sensory Organ Evolution in Jawed Vertebrates.

Cartilaginous fishes (chondrichthyans: chimeras and elasmobranchs -sharks, skates, and rays) hold a key phylogenetic position to explore the origin and diversifications of jawed vertebrates. Here, we report and integrate reference genomic, transcriptomic, and morphological data in the small-spotted catshark Scyliorhinus canicula to shed light on the evolution of sensory organs. We first characterize general aspects of the catshark genome, confirming the high conservation of genome organization across cartilaginous fishes, and investigate population genomic signatures.

Automated hippocampal sparing whole brain radiotherapy with simultaneous integrated boost for multiple brain metastases: Halcyon, HyperArc on TrueBeam, and coplanar TrueBeam.

Purpose: To demonstrate the ease and feasibility that hippocampal sparing whole brain (WB) simultaneous integrated boost (HSWB-SIB) plans can be generated using knowledge-based planning and Eclipse Scripting Application Programming Interface (ESAPI) for three different modalities, HyperArc on TrueBeam (TB-HA), a coplanar beam arrangement on TrueBeam (TB-Co), and the ring-mounted Halcyon LINAC (Hal).

Methods: Twelve patients with 2-14 brain metastases were retrospectively replanned for HSWB-SIB using a published HSWB RapidPlan model with modifications for the automated addition of SIB to metastases. Prescribed dose was 30 Gy to the WB planning target volume (PTV) and 50 Gy to the metastases in 10 fractions.

A chromosomal reference genome sequence for the malaria mosquito, , Theobald, 1903.

We present a genome assembly from an individual female (the malaria mosquito; Arthropoda; Insecta; Diptera; Culicidae) from Lopé, Gabon. The genome sequence is 225.7 megabases in span.

The Hypolimnas misippus Genome Supports a Common Origin of the W Chromosome in Lepidoptera.

Moths and butterflies (Lepidoptera) have a heterogametic sex chromosome system with females carrying ZW chromosomes and males ZZ. The lack of W chromosomes in early-diverging lepidopteran lineages has led to the suggestion of an ancestral Z0 system in this clade and a B chromosome origin of the W. This contrasts with the canonical model of W chromosome evolution in which the W would have originated from the same homologous autosomal pair as the Z chromosome.

Chromosomal reference genome sequences for the malaria mosquito, , Laveran, 1900.

We present genome assembly from individual female (African malaria mosquito; Arthropoda; Insecta; Diptera; Culicidae) from Lopé, Gabon. The genome sequence is 270 megabases in span. Most of the assembly is scaffolded into three chromosomal pseudomolecules with the X sex chromosome assembled for both species.

The genome sequence of the Dracula fish, (Britz, Conway & Rüber, 2009).

We present a genome assembly from an individual (the Dracula fish; Chordata; Actinopterygii; Cypriniformes; Danionidae; Danioninae). The genome sequence is 665.21 megabases in span.

Effects of reducing sedentary behaviour by increasing physical activity, on cognitive function, brain function and structure across the lifespan: a systematic review and meta-analysis.

Objective: To examine the acute and chronic effects of reducing prolonged sedentary time (ST) with physical activity (PA) on cognitive and brain health.

Design: Systematic review and meta-analysis.

Data Sources: PubMed, Scopus, CINAHL, PsycINFO, SPORTDiscus, Web of Science, and ProQuest Dissertation and Theses.

Genomic evidence reveals three W-autosome fusions in Heliconius butterflies.

Sex chromosomes are evolutionarily labile in many animals and sometimes fuse with autosomes, creating so-called neo-sex chromosomes. Fusions between sex chromosomes and autosomes have been proposed to reduce sexual conflict and to promote adaptation and reproductive isolation among species. Recently, advances in genomics have fuelled the discovery of such fusions across the tree of life.

Temporal genomics in Hawaiian crickets reveals compensatory intragenomic coadaptation during adaptive evolution.

Theory predicts that compensatory genetic changes reduce negative indirect effects of selected variants during adaptive evolution, but evidence is scarce. Here, we test this in a wild population of Hawaiian crickets using temporal genomics and a high-quality chromosome-level cricket genome. In this population, a mutation, flatwing, silences males and rapidly spread due to an acoustically-orienting parasitoid.

Stereotactic radiotherapy of intracranial tumor beds on a ring-mounted Halcyon LINAC.

Purpose: This study sought to evaluate the feasibility and efficacy of the Halcyon Ring Delivery System (RDS) for delivering stereotactic radiotherapy (SRT) treatments for intracranial tumors beds.

Methods: Ten previously treated brain SRT patients for 30 Gy in five fractions with non-coplanar HyperArc plans on TrueBeam (6MV-FFF) were replanned on Halcyon (6MV-FFF) using the same number of arcs and Eclipse's AcurosXB dose engine. Plan quality evaluation metrics per SRT protocol included: PTV coverage, GTV dose (minimum and mean), target conformity indices (CI), heterogeneity index (HI), gradient index (GI), maximum dose 2 cm away from the PTV (D), and doses to organs-at-risk (OAR).