Publications by authors named "Shagayegh Javadzadeh"
Article Synopsis
- A 47-year-old woman with several autoimmune and metabolic conditions presented with a painful skin rash characterized by raised, yellow-centered plaques on sun-exposed areas.
- A biopsy revealed specific histopathological features that led to a diagnosis of annular elastolytic giant cell granuloma (AEGCG), a rare inflammatory skin disorder potentially triggered by sunlight exposure.
- The patient showed significant improvement after being treated with ciclosporin, alleviating symptoms like itching and pain, highlighting the challenges in managing AEGCG, which is often resistant to standard treatments.
Background: Recording large-group lectures is commonplace in higher education, allowing students to access content asynchronously and remotely. With the move towards online learning during the COVID-19 pandemic, recording of small-group teaching sessions has also become increasingly common; however, the educational value of this practice is unknown.
Methods: All medical students rotating through the Acute Medicine Department of a large teaching hospital were invited to enrol in the study.
Article Synopsis
- Atopic eczema is a prevalent and complicated disease, potentially influenced by environmental factors rather than just genetics, particularly in industrializing nations.
- A study conducted from May 2018 to March 2020 focused on eczema severity in younger Bangladeshi individuals in East London, examining the connection between weather and pollution.
- Results indicated that long-term exposure to high levels of ground-level ozone was strongly linked to more severe eczema, with fine particulate matter acting as a secondary factor.
Evidence shows dwindling levels of bedside teaching for medical students in the UK, especially in district general hospitals. Lack of individual responsibility has resulted in disengagement in teaching. Based on a quality improvement project (QIP) at a District General Hospital, we suggest some ways this could be addressed.
View Article and Find Full Text PDFContext: Verbal descriptors are important in understanding patients' experience of breathlessness.
Objectives: The aim of this study was to examine the association between selection of breathlessness descriptors, diagnosis, self-reported severity of breathlessness and self-reported distress due to breathlessness.
Methods: We studied 132 patients grouped according to their diagnosis of advanced chronic obstructive pulmonary disease (n = 69) or advanced cancer (n = 63), self-reported severity of breathlessness as mild breathlessness (Numerical Rating Scale [NRS] ≤ 3, n = 53), moderate breathlessness (4 ≤ NRS ≥ 6, n = 59) or severe breathlessness (NRS ≥ 7, n = 20), and distress due to breathlessness as mild distress (NRS ≤ 3, n = 31), moderate distress (4 ≤ NRS ≥ 6, n = 44), or severe distress (NRS ≥ 7, n = 57).
Uterine NK cells are innate lymphoid cells (ILC) that populate the uterus and expand during pregnancy, regulating placental development and fetal growth in humans and mice. We have recently characterized the composition of uterine ILCs (uILCs), some of which require the transcription factor NFIL3, but the extent to which NFIL3-dependent cells support successful reproduction in mice is unknown. By mating Nfil3 (-/-) females with wild-type males, here we show the effects of NFIL3 deficiency in maternal cells on both the changes in uILCs during pregnancy and the downstream consequences on reproduction.
View Article and Find Full Text PDFObjectives: Breathlessness is common in patients with advanced cancer and almost universal in advanced chronic obstructive pulmonary disease (COPD), but studies suggest their experiences of breathlessness vary. This report builds on these studies by providing quantitative evidence of differences in respiratory health-related quality of life (HRQoL) between these groups. Further, it explores the validity of the Chronic Respiratory Questionnaire (CRQ) in patients with cancer.
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