Comparing Medical and Surgical Management of Chronic Rhinosinusitis: A Systematic Review of Dupilumab and Endoscopic Sinus Surgery.

Chronic rhinosinusitis (CRS) is a multifactorial condition that significantly impacts patients' quality of life through persistent nasal obstruction, loss of smell, and facial pain. Endoscopic sinus surgery (ESS) has historically been the definitive option for patients who fail first-line therapies, yet emerging evidence suggests that Dupixent (dupilumab), an IL-4/IL-13 inhibitor, may provide robust medical management by directly targeting the underlying type 2 inflammatory pathways. This systematic review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, examining randomized clinical trials and prospective intervention studies identified through multiple databases.

Comparative Efficacy of Dexmedetomidine and Remifentanil in Reducing Postoperative Pain and Opioid Use: A Systematic Review.

Postoperative pain management is a critical component of patient care following surgical procedures. Opioid analgesics, particularly Remifentanil, have been traditionally used to manage pain, but these drugs come with significant risks, including opioid-induced hyperalgesia (OIH) and the potential for dependence on opioids. Dexmedetomidine, an alpha-2 adrenergic receptor agonist, is a promising non-opioid alternative.