Comparative analysis of neurosteroid levels in normal and adenomatous human pituitary tissue.

Neurosteroids (NS) are neuroactive steroid hormones, synthesized in the nervous system. Prior research on NSs in pituitary tissue relied on animal investigations. The complete knowledge regarding the presence of these distinct hormones in the human pituitary gland is lacking.

Lateralization outcomes of bilateral inferior petrosal sinus sampling: desmopressin vs CRH.

Purpose: Bilateral inferior petrosal sinus sampling (BIPSS) is the gold standard for localizing ACTH-dependent Cushing's syndrome (CS). While corticotropin-releasing hormone (CRH) was initially used for stimulation, desmopressin has become a common alternative. This research evaluates desmopressin's effectiveness in lateralizing Cushing's disease (CD) during BIPSS compared to CRH stimulation.