Publications by authors named "Seung Namgung"
Objective: To define the effects of Xanthoceras sorbifolia (EXS) on vascular inflammation and the mechanisms in endothelial cells.
Methods: Vascular protective effects of an ethanol extract of seeds from EXS (1-50 μg/mL) against tumor necrosis factor-α (TNF-α)-induced vascular inflammation were examined in human umbilical vein endothelial cells (HUVECs).
Results: EXS significantly decreased TNF-α-induced expression of cell adhesion molecules, such as intracellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial cell selectin, in a dose-dependent manner.
Renal mesangial cell proliferation is a major clinical feature of diabetic nephropathy (DN) and includes glomerulosclerosis and renal fibrosis. Samchuleum (SCE) is a traditional herbal mixture that is recorded in the ancient Korean medical book, Donguibogam. The present study attempted to determine whether SCE treatment was able to improve high glucose (HG)‑induced mesangial cell fibrosis and glomerulosclerosis in primary cultured human mesangial cells.
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- The study investigated the effects of Hwangryunhaedoktang (HHT), a herbal compound, on inflammation caused by lipopolysaccharides (LPS) in macrophage cells called RAW264.7.
- Results showed that HHT reduced nitric oxide production and the expression of inflammatory markers in a dose-dependent manner, while inhibiting key signaling pathways, including NF-κB and MAPKs, associated with inflammation.
- The findings suggest that HHT could have potential therapeutic benefits for managing inflammation by decreasing the secretion of pro-inflammatory cytokines like TNF-α and IL-6.
[Purpose] The purpose of this study is to examine the effect of calf muscle massage on ankle flexibility and balance. [Subjects and Methods] The study's subjects were 32 healthy college students, divided into two groups according to the massage methods applied. Both groups received five-minutes of massage to each calf, making a total of ten minutes.
View Article and Find Full Text PDFPrunella vulgaris Attenuates Diabetic Renal Injury by Suppressing Glomerular Fibrosis and Inflammation.
Am J Chin Med
September 2017
Article Synopsis
- Diabetic nephropathy is a major complication of diabetes that leads to high mortality, prompting research into treatments.
- An aqueous extract of Prunella vulgaris (APV) was found to reduce renal inflammation and fibrosis in human mesangial cells and diabetic rat models by affecting key signaling pathways associated with injury.
- Results showed that APV decreased biomarkers of fibrosis and inflammation, improved kidney function, and may serve as a potential therapy for conditions leading to diabetic nephropathy.
Tsukamurella pulmonis is an aerobic actinomycete. We report a catheter-related bacteremia of T. pulmonis.
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