Selective ERα Attenuates Hypothalamic ER Stress and Regulates Energy Homeostasis in Ovariectomized Mice Fed With High-Fat Diet.

Obesity is often caused by an imbalance between energy intake and expenditure, with the hypothalamus essential in maintaining this balance, and any impairment in its function can contribute to obesity. Estrogen receptor alpha (ERα) plays a significant role in controlling body weight by influencing energy intake. However, the specific processes through which ERα exerts its anorexigenic effects remain insufficiently understood.