Cinnamic acid ameliorates diabetic nephropathy in rats Nrf2 activation and inflammation modulation.

This study investigates the therapeutic effects of cinnamic acid (CA) on diabetic nephropathy (DN) and elucidates its mechanisms involving Nrf2 activation and NF-κB suppression. Type 2 diabetes mellitus (T2DM) was induced in Wistar rats through a high-fat diet followed by streptozotocin administration. Rats were assigned to each of the six groups: control, control + CA (40 mg kg), T2DM, T2DM + CA (20 mg kg), T2DM + CA (40 mg kg), and T2DM + CA (40 mg kg) with brusatol (an Nrf2 inhibitor; 2 mg per kg per twice per week).

Therapeutic Potential of Cinnamic Acid as an SGLT2 Inhibitor in Mitigating Diabetic Nephropathy in a Rat Model of Type 2 Diabetes.

This study investigates the renal protective effects of cinnamic acid (CA) in a Type 2 diabetes mellitus (T2DM) rat model induced by high-fat diet (HFD) and streptozotocin (STZ), with a focus on its potential as a natural hypoglycemic agent and SGLT2 inhibitor. In a randomized design, five groups of rats (n = 8) were administered different treatments for 8 weeks: Control, Control + CA (40 mg/kg), T2DM, T2DM + CA (20 mg/kg), and T2DM + CA (40 mg/kg). CA treatment (20 and 40 mg/kg) significantly improved the glomerular and tubular structure in T2DM group, with normal features observed at the highest dose.

Isoliquiritigenin Prevents the Development of Nephropathy by an HFD in Rats Through the Induction of Antioxidant Production and Inhibition of the MD-2/TLR4/NF-κB Pathway.

This study tested the ISL against renal damage induced by a high-fat diet (HFD) and explored its underlying mechanisms. Adult male rats were assigned to four groups: (1) control on a standard diet (STD), (2) ISL on STD (30 mg/kg), (3) HFD, and (4) HFD + ISL (30 mg/kg). After 12 weeks of dietary intervention, ISL treatment led to significant reductions in body weight gain, visceral fat, and glucose and insulin levels in HFD-fed rats.

Phytochemical Screening and Antimicrobial Activity of Methanolic Extract of (L.) (azkhar) Collected from Afif City, Saudi Arabia.

In Saudi Arabia, (L.) has been traditionally used to treat a variety of diseases. This study aimed to investigate the crude methanolic extract of (L.