Glioblastoma and Blood Microenvironment Predictive Model for Life Expectancy of Patients.

Glioblastoma multiforme (GBM) is a very malignant brain tumor. GBM exhibits cellular and molecular heterogeneity that can be exploited to improve patient outcomes by individually tailoring chemotherapy regimens. Our objective was to develop a predictive model of the life expectancy of GBM patients using data on tumor cells' sensitivity to chemotherapy drugs, as well as the levels of blood cells and proteins forming the tumor microenvironment.

Glioblastoma Multiforme: Sensitivity to Antimicrobial Peptides LL-37 and PG-1, and Their Combination with Chemotherapy for Predicting the Overall Survival of Patients.

Glioblastomas (GBMs) are the most malignant and intractable of all cancers, with an unfavorable clinical prognosis for affected patients. The objective was to analyze the sensitivity of GBM cells to the antimicrobial peptides (AMPs) cathelicidin (LL-37) and protegrin-1 (PG-1), both alone and in combination with chemotherapy, to predict overall survival (OS) in the patients. The study was conducted on 27 GBM patients treated in the neurosurgical department of the Almazov Medical Research Centre (Saint Petersburg, Russia) from 2021 to 2024.

The inhibitory effect of meadowsweet (Filipendula ulmaria) on radiation-induced carcinogenesis in rats.

Purpose: To examine the ability of the meadowsweet preparation to inhibit carcinogenesis induced by ionizing radiation in female rats.

Materials And Methods: The chemical composition of meadowsweet (Filipendula ulmaria) raw material (ethanol and aqueous extracts of meadowsweet flowers) has been studied for the presence of flavonoids, tannins and catechins. Adult female LIO strain rats were subjected to a single whole body γ-irradiation at a dose of 4 Gy in animal experiments.

Anticarcinogenic activity of alpha-difluoromethylornithine, ginseng, eleutherococcus, and leuzea on radiation-induced carcinogenesis in female rats.

Purpose: To carry out a comparative study of inhibition of radiation carcinogenesis using alpha-difluoromethylornithine (DFMO), tinctures of ginseng, eleutherococcus and leuzea in female rats.

Materials And Methods: Locally bred female LIO-strain rats were subjected to a single whole body γ-irradiation dose of 4 Gy at 12 weeks of age. Modifying drugs were given with drinking water from the 10th day after irradiation until the end of the experiment (for 16 months).

Blood DNA radiosensitivity may be predictive for efficacy of experimental glioma irradiation: an animal study.

Objective: An animal study was conducted to evaluate the -association between blood DNA radiosensitivity, assessed by determining the original S-index, and the response of experimental gliomas to irradiation. Possible modifications of the latter after administration of iron-containing water (ICW) were also explored.

Methods: The study was performed on Wistar rats with subcutaneously implanted experimental glioma-35.