Publications by authors named "Seong-Hyeok Choi"
Objectives: Despite the availability of bivalent vaccines targeting both the ancestral SARS-CoV-2 strain and Omicron subvariants, vaccination rates remain low in South Korea. This study aims to evaluate the neutralizing activity against Omicron subvariants following the third SARS-CoV-2 vaccination in patients undergoing chemotherapy, as well as to assess the need for additional vaccinations.
Methods: Between April and November 2022, the authors assessed the neutralizing activity of the third SARS-CoV-2 vaccine dose in 63 patients undergoing chemotherapy using an ELISA-based surrogate Virus Neutralization Test (sVNT).
Is Treosulfan-Based Conditioning Attractive as a Reduced-Intensity Conditioning Regimen in Korea?
J Korean Med Sci
September 2023
Background: Allogeneic hematopoietic stem cell transplantation (HSCT) was not actively performed in elderly acute myeloid leukemia (AML) or myelodysplastic syndrome patients who are at a high-risk based on hematopoietic cell transplantation-specific comorbidity index (HCT-CI). The advent of reduced-intensity conditioning (RIC) regimens has made HSCT applicable in this population. However, the selection of appropriate conditioning is a major concern for the attending physician.
View Article and Find Full Text PDFArticle Synopsis
- A study in South Korea explored the need for a fourth COVID-19 vaccine dose among healthcare workers (HCWs) by examining their infection rates and immune responses eight months after the third dose.
- Of the 43 HCWs studied, 65.1% were infected with the presumed omicron variant, mostly within four months post-vaccination, but all experienced mild symptoms.
- Results indicated that those infected had significantly higher levels of antibody response compared to uninfected individuals, suggesting that hybrid immunity from prior infection and vaccination may reduce the urgency for a fourth dose in these HCWs.
Aim: This study examined the serum antibody response of coronavirus disease 2019 (COVID-19) vaccines in solid and hematologic cancer patients undergoing chemotherapy. Levels of various inflammatory cytokines/chemokines after full vaccination were analyzed.
Methods: Forty-eight patients with solid cancer and 37 with hematologic malignancy who got fully vaccinated either with severe acute respiratory syndrome coronavirus 2 messenger RNA (mRNA) or vector vaccines or their combination were included.
Background: Although the primary vaccine coverage rate for coronavirus disease 2019 (COVID-19) in South Korea has exceeded 80%, the coronavirus continues to spread, with reports of a rapid decline in vaccine effectiveness. South Korea is administering booster shots despite concerns about the effectiveness of the existing vaccine.
Methods: Neutralizing antibody inhibition scores were evaluated in two cohorts after the booster dose.
Article Synopsis
- The COVID-19 pandemic necessitated diverse vaccination strategies in Korea, focusing on healthcare workers due to their higher risk of infection.
- A study evaluated the adverse events (AEs) and immune responses of BNT162b2 versus ChAdOx1 vaccines, enrolling 115 fully vaccinated healthcare workers, with blood samples taken after both vaccinations.
- Results showed that the BNT162b2 vaccine had a significantly stronger neutralizing antibody response and overall better quality of immune response, though both vaccines ensured high seropositivity among participants.
NaOH-HCl neutralized urine preparation for direct testing of uropathogens by Bruker MS.
J Clin Lab Anal
March 2018
Background: We evaluated the analytical performance of a NaOH-HCl neutralization protocol for identifying uropathogens directly from urine samples by a Bruker MS system (Bruker Daltonics, German) and sought to establish a protocol for integrating the method with conventional screening.
Methods: Among all urine samples requested for Gram staining, UF-1000i, and urine cultures by physicians, we selected samples that were positive by both Gram staining and UF-1000i testing. Urine was prepared by neutralization using 0.