Publications by authors named "Sean Inzerillo"
Management of traumatic brain injury (TBI) patients on pre-TBI antithrombotic medications poses a clinical challenge in everyday practice. However, the safety profiles of antiplatelets (APs) have not been systematically studied and compared to anticoagulants (ACs) in this patient population. In this PRISMA-compliant systematic review the EMBASE and MEDLINE databases were systematically queried to identify comparative studies in patients with TBI and pre-injury AP and AC medications.
View Article and Find Full Text PDFObjective: To identify predictors for time to first treatment modality (TTT) in patients diagnosed with spinal metastatic disease.
Methods: Our radiology database was retrospectively queried to identify patients with spinal metastases (01/2017-12/2021). Demographics, setting of initial imaging (inpatient/outpatient/ED), histology, treatment modality, and TTT were collected.
Objectives: To evaluate factors associated with clinic follow-up after traumatic spinal injury (TSI) in Tanzania, focusing on demographic, injury-related and hospital variables. We hypothesised that socioeconomic and injury-specific factors would predict follow-up adherence.
Design: Retrospective observational cohort study.
Background: Severe isolated traumatic brain injury (TBI) represents a complex and understudied population. Limited evidence exists on predictors of cranial decompression. This study aims to quantify the rate and identify factors associated with cranial decompression in severe isolated TBI using a large national database.
View Article and Find Full Text PDFPurpose: This study investigates key prognostic factors influencing morbidity and mortality in pediatric diffuse axonal injury (DAI) using nationally collected data from the American College of Surgeons (ACS) Trauma Quality Program (TQP) to inform clinical practice and future research.
Methods: The ACS-TQP database (2019-2021) was analyzed for pediatric DAI cases, excluding those with intracranial hemorrhages or pre-admission deaths. Demographics and clinical characteristics were compared across age groups (0-3, 4-12, 13-17), and multivariate regression identified predictors of mortality, complications, intensive care unit (ICU) stay, and ventilator duration.
Introduction: Expandable cages are designed to address the limitations of static cages in minimally invasive transforaminal lumbar interbody fusion (MI-TLIF). These devices enable collapsed insertion with in-situ expansion, aiming to restore disc height and lordosis, indirect foraminal decompression, and sagittal alignment with reduced neural and tissue trauma. Advancements in bi-dimensional cage expansion, endplate interaction, and innovative materials have been designed in attempt to improve fusion rates and clinicoradiographic outcomes.
View Article and Find Full Text PDFMinimally invasive spine surgery (MISS) has transformed spinal surgery by minimizing tissue disruption, reducing recovery times, and lowering complication rates compared with traditional open procedures. MISS uses smaller incisions, specialized tools, and advanced imaging to treat conditions such as degenerative disk disease, trauma, and tumors. Techniques such as endoscopic spine surgery and tubular retractors have expanded its applications, enabling effective treatment with less postoperative pain and faster mobilization.
View Article and Find Full Text PDFBackground: Early diagnosis of degenerative cervical myelopathy (DCM) is often challenging due to subtle, non-specific symptoms, limited disease awareness and a lack of definitive diagnostic criteria. As primary care physicians are typically the first to encounter patients with early DCM, equipping them with effective screening tools is crucial for reducing diagnostic delays and improving patient outcomes. This systematic review evaluates the efficacy of quantitative screening methods for DCM that can be implemented in primary care settings.
View Article and Find Full Text PDFArticle Synopsis
- Minimally invasive spine surgery (MISS) reduces tissue damage through small incisions and advanced techniques, leading to benefits like less blood loss and shorter hospital stays compared to traditional open surgery.
- * A systematic review of literature from Jan 2013 to Mar 2024 analyzed complications related to MISS, finding that various complications (like nerve injuries and cerebrospinal fluid leaks) depend on the specific surgical approach (cervical, thoracic, or lumbar).
- * Although MISS generally lowers the risk of anatomical disruption, certain complications can still occur; the use of intraoperative monitoring and advanced technology may reduce these risks further, establishing MISS as a safe alternative to open surgery.
Article Synopsis
- This pilot study explores how using monetary incentives via an app can help improve patients' adherence to important preoperative and postoperative instructions.
- Conducted at Maimonides Medical Center, participants received rewards for completing specific health-related tasks through the TheraPay Rewards app, targeting both English and Spanish speakers.
- The results showed high adherence rates for preoperative tasks (about 98.7%), but significantly lower rates for postoperative tasks (around 60%), indicating the potential of financial incentives while also noting the need for improved support post-surgery.
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- The pandemic negatively impacted the care for patients with rheumatic diseases, leading to access difficulties and psychologically affecting their quality of life.
- A survey comparing patient and provider experiences with telemedicine was conducted in 2020 and 2021, revealing increased patient satisfaction and comfort with telemedicine services, while providers had mixed feelings about its effectiveness compared to in-person visits.
- Overall, while patients showed a strong preference for telemedicine and reported similar quality of life as pre-pandemic levels, the difference in satisfaction between patients and providers raises questions about the viability of telemedicine as a long-term alternative to traditional care.
Article Synopsis
- * Findings show that patients with SLE have a weaker immune response to vaccines compared to healthy individuals and that certain immunosuppressive medications may reduce vaccine effectiveness, but they don’t increase the risk of disease flare-ups or side effects.
- * The overall safety of COVID-19 vaccines for AIIRD patients is confirmed, and the benefits of vaccination are considered to significantly outweigh the risks; further research is needed on booster doses and managing immunosuppressant treatments around vaccination.
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- - Glycans, which are sugar molecules found on the surfaces of cells, play crucial roles in how bacteria interact with their hosts, affecting both bacterial colonization and the immune responses of the host.
- - The review covers three main topics: the role of bacterial glycans in pathogenesis, the use of host glycans by bacteria, and the involvement of both in immune responses.
- - It highlights future directions for research in glycoscience, including the development of new antibacterial strategies to combat drug-resistant pathogens.
Article Synopsis
- * The study involved modifying and comparing the effectiveness of different monoclonal antibodies against CR- sequence type 258 (ST258), with findings indicating that murine IgG (mIgG) had superior binding, agglutination, and bactericidal activity compared to other antibody forms.
- * Results suggest that mIgG could be a viable adjunctive therapy for neutropenic patients at high risk for CR- infections, highlighting its potential role in addressing the urgent public health threat posed by antibiotic resistance.