Publications by authors named "Sarju D Patel"
Article Synopsis
- * In a study using an autoimmune model, researchers found that a high dose of a specific myelin protein failed to cause disease, unlike a lower dose, even though the number of harmful T cells was similar in both cases.
- * Interestingly, T cells exposed to the high dose became unresponsive, showing increased PD-1 expression, yet the removal of PD-1 didn’t change their unresponsive state, highlighting a different mechanism in this context compared to other diseases.
Extensive cross-reactivity in T cell receptor (TCR) recognition of peptide-MHC (pMHC) complexes seems to be essential to give sufficient immune surveillance against invading pathogens. This carries with it an inherent risk that T cells activated during a response to clear an infection can, perhaps years later, respond to a self pMHC of sufficient similarity. This lies at the heart of the molecular mimicry theory.
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