Sex differences in cerebral pulsatility and damping: A 4D flow MRI study.

Cerebral pulsatility is a potential marker of cerebrovascular health, yet little is understood about sex differences in cerebral pulsatility with age, especially within different cerebral arteries. Additionally, cerebral damping can blunt cerebral pulsatility and might decline with age. Therefore, we aimed to identify sex differences in cerebral pulsatility and damping across the adult lifespan.

Biological sex influences relationships between cerebral pulsatility and white matter hyperintensities in aging adults.

Arterial stiffening with age, which is associated with elevated cerebral pulsatility in the intracranial arteries, is linked to structural alterations in the brain, including white matter hyperintensities (WMH). Biological sex differences exist in cerebral hemodynamics and Alzheimer's disease (AD) risk; yet, little is known regarding the impact of biological sex on the association between cerebral pulsatility and WMH. We studied 403 cognitively unimpaired middle-aged and older adults (45-91 yr, 272 females) who completed 3 T magnetic resonance imaging (MRI).

Central arterial stiffness, wave reflection, and heart rate variability following 4-week high-intensity resistance training intervention in young active women.

Purpose: Arterial stiffness, expedited wave reflection, and autonomic dysfunction are risk factors for cardiovascular disease, which is the leading cause of death in women in the United States. Evaluation of the effects of resistance training on these factors has been inconclusive, and even less is known about the effects of high-intensity resistance training (HIRT). This study evaluated the effects of a 4-week HIRT intervention on central arterial stiffness, wave reflection, and heart rate variability in young healthy and active women.