Association of coagulation dysfunction with thrombosis, bleeding and mortality in patients supported by veno-venous extracorporeal membrane oxygenation for viral pneumonia.

Background: Bleeding and thrombosis remain leading causes of morbidity and mortality in patients supported by extracorporeal membrane oxygenation (ECMO).

Aims: Assess haemostatic changes during veno-venous (VV)-ECMO support after respiratory failure due to viral pneumonia and their association with major bleeding, thrombosis and mortality.

Methods: Coagulation factors (II, V, VII, VIII, IX, X, XI, XII), von-Willebrand profile and thrombin generation (TG) were measured at cannulation, during VV-ECMO (every 5 day), 1hr and 24hrs-post decannulation in 50 patients (Aug 2018-Jan 2020).

Thrombocytosis and bleeding in myeloproliferative neoplasms: exploring clinical diversity and risk of acquired von Willebrand syndrome-insights from a UK center.

Background: Myeloproliferative neoplasms (MPNs) represent a group of blood disorders characterized by myeloid cell proliferation and an associated increased risk of thrombosis and bleeding. Platelet count may have a direct link to these complications.

Objectives: To share our MPN clinic's experience with hemostatic testing and bleeding outcomes in patients with platelets ≥ 800 × 10/L.

Evaluation of von Willebrand factor concentrates by platelet adhesion to collagen using an in vitro flow assay.

Background: Von Willebrand disease (VWD) results from quantitative or qualitative deficiency of von Willebrand factor (VWF) and is treated using VWF-containing concentrates. Several studies have compared the function of various VWF containing concentrates however this has not been performed using shear based assays.

Objectives: To compare the platelet-capture potential of 10 commercially available, plasma-derived VWF concentrates under shear conditions.