Publications by authors named "Sarah D Kaye"
MICU1's calcium sensing beyond mitochondrial calcium uptake.
Biochim Biophys Acta Mol Cell Res
June 2024
The discovery of MICU1 as gatekeeper of mitochondrial calcium (Ca) entry has transformed our understanding of Ca flux. Recent studies revealed an additional role of MICU1 as a Ca sensor at MICOS (mitochondrial contact site and cristae organizing system). MICU1's presence at MICOS suggests its involvement in coordinating Ca signaling and mitochondrial ultrastructure.
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- Brain-derived extracellular vesicles (EVs) are key players in Alzheimer's disease, acting as potential biomarkers due to the protection of their internal cargo from degradation.
- * A new method was developed to collect EVs from the hippocampal interstitial fluid of live mice, with specific techniques used for isolation and characterization.
- * Findings indicate that, in a model of Alzheimer’s, the protein concentration in EVs increases while protein diversity decreases with amyloid-beta deposition, and notable differences were observed based on sex regarding microglial EV proteome.
Elevated blood glucose levels, or hyperglycemia, can increase brain excitability and amyloid-β (Aβ) release, offering a mechanistic link between type 2 diabetes and Alzheimer's disease (AD). Since the cellular mechanisms governing this relationship are poorly understood, we explored whether ATP-sensitive potassium (KATP) channels, which couple changes in energy availability with cellular excitability, play a role in AD pathogenesis. First, we demonstrate that KATP channel subunits Kir6.
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- Brain-derived extracellular vesicles (EVs) are important in Alzheimer's disease (AD) as they contain physiological information about brain regions and could serve as AD biomarkers due to their stability in circulation.
- A new method was developed to collect these EVs from the hippocampal interstitial fluid of live mice, revealing specific characteristics and size dimensions alongside conducting proteomic analyses.
- In a mouse model of cerebral amyloidosis, findings indicated that while protein concentration in EVs increased with amyloid plaque deposition, the diversity of proteins decreased, and that these changes varied based on genotype, age, and sex, highlighting different microglial responses in female mice.