Genomic and immune profiling of prognostic risk groups in IgM gammopathy reveals novel biomarkers beyond L265P.

Background: L265P is an early mutation in IgM monoclonal gammopathy of undetermined significance (MGUS) and asymptomatic Waldenström macroglobulinemia (WM). Given the high prevalence of the mutation observed in epidemiological studies, its presence is not sufficient to drive disease progression. In fact, a recent risk model of progression reported that the impact of other laboratory biomarkers was superior to the mutation's presence.

Midwifery theories: A scoping review.

Problem: The identification of midwifery theories will contribute to the identification of a midwifery model of care for women experiencing low-risk pregnancies, and to support its implementation in Portugal.

Background: Previous research has explored the concept of woman-centredness as the core principle underpinning midwifery practice, mapped existing midwifery models of care, synthesized multiple theories and the scope of midwifery to achieve conceptual integration, and identified the aspects of midwifery care that most significantly contribute to the quality of care for women and their babies. However, to the best of the authors' knowledge, no other review has mapped the theories that underpin midwifery practice.

Germ line variants in patients with acute myeloid leukemia without a suspicion of hereditary hematologic malignancy syndrome.

Germ line predisposition in acute myeloid leukemia (AML) has gained attention in recent years because of a nonnegligible frequency and an impact on management of patients and their relatives. Risk alleles for AML development may be present in patients without a clinical suspicion of hereditary hematologic malignancy syndrome. In this study we investigated the presence of germ line variants (GVs) in 288 genes related to cancer predisposition in 47 patients with available paired, tumor-normal material, namely bone marrow stroma cells (n = 29), postremission bone marrow (n = 17), and saliva (n = 1).

Prognostic impact of MYD88 and CXCR4 mutations assessed by droplet digital polymerase chain reaction in IgM monoclonal gammopathy of undetermined significance and smouldering Waldenström macroglobulinaemia.

Waldenström macroglobulinaemia (WM) is characterized by recurrent somatic mutations in MYD88 and CXCR4 genes. However, limitations arise when analysing these mutations in IgM monoclonal gammopathy of undetermined significance (MGUS) or smouldering WM (SWM) given the lower tumour load. Here, we used droplet digital polymerase chain reaction (ddPCR) to analyse MYD88 L265P and CXCR4 S338* mutations (C1013G and C1013A) in unsorted bone marrow (BM) or cell-free DNA (cfDNA) samples from 101 IgM MGUS and 69 SWM patients.

Impact of desensitizing/whitening toothpastes on tooth color change after abrasion and erosion-abrasion.

Objective: To evaluate the impact of desensitizing toothpastes (D), their whitening versions (DW) and whitening toothpastes (W) on tooth color change.

Methods: Tooth specimens were allocated into 11 groups (n = 10): 1. Artificial saliva (control); 2.

Role of desensitizing/whitening dentifrices in enamel wear.

Objectives: To analyze the impact of desensitizing (D) and/or whitening (W) dentifrices on erosion and erosion-abrasion.

Methods: Enamel specimens were allocated into 10 groups (n = 20): 1. Artificial saliva (control); 2.