Predicting Chemotherapy-Induced Peripheral Neuropathy Using Transformer-Based Multimodal Deep Learning.

Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating adverse effect of cancer treatment that substantially impairs patients' quality of life and may lead to dose reduction or treatment discontinuation. Traditional prediction models based on single-modal data have shown limited accuracy in clinical settings. This study aimed to develop and evaluate a deep learning-based predictive model for CIPN by integrating multimodal data, including clinical, genomic, biosignal, wearable device, and imaging information.

The Process of Cancer Prevention Behaviors in Individuals at High Risk of Hereditary Cancer: A Grounded Theory Study.

Objective: This study aimed to explore the process of cancer prevention behaviors in individuals at high risk of hereditary cancer in Korea.

Methods: We included 10 adults with pathogenic variants in genes related to hereditary breast and ovarian cancer syndrome, hereditary non-polyposis colorectal cancer, or familial adenomatous polyposis, but who had never been diagnosed with cancer. Data were collected through in-depth interviews at the cancer prevention center of a tertiary hospital in Korea.

Impact of comorbidities on health-related quality of life in diabetic patients: Evidence from a South Korean population-based panel study.

ObjectiveThis study employed data derived from a nationally representative panel survey to investigate the impact of comorbidities on the health-related quality of life (HRQoL) of individuals living with diabetes mellitus.MethodsA retrospective, cross-sectional, population-based analysis was conducted using data from 10,049 participants in the Korea Health Panel Survey (KHPS) in 2020. The participants were divided into three groups: individuals without diabetes, individuals with diabetes only, and individuals with diabetes and comorbidities.

Implementation of Integrated Smart Construction Monitoring System Based on Point Cloud Data and IoT Technique.

This study presents an integrated smart construction monitoring system that combines point cloud data (PCD) from a 3D laser scanner with real-time IoT sensors and ultra-wideband (UWB) indoor positioning technology to enhance construction site safety and quality management. The system addresses the limitations of traditional BIM-based methods by leveraging high-precision PCD that accurately reflects actual site conditions. Field validation was conducted over 17 days at a residential construction site, focusing on two floors during concrete pouring.

Chemotaxis of Miamiensis avidus to hyaluronic acid, a component of fish surface mucus.

Miamiensis avidus is a marine parasitic ciliate belonging to the order Scuticociliatida, the members of which are the causal agents of scuticociliatosis. This ciliate has resulted in considerable economic losses to the aquaculture industry in the Republic of Korea and Japan. Nevertheless, the development of vaccines and therapeutics has proven to be challenging, and there are currently no reports of such products commercially available in Korea or Japan.

Methyl-oxazolomycin A: A novel oxazolomycin analog with potent selective estrogen receptor degrading activity in breast cancer cells.

Breast cancer (BC), the most prevalent malignancy in women worldwide, is categorized according to the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) in tumor cells. Approximately 70% of all BCs are ER-positive and HER2-negative, and estrogen binding to the ER plays a vital role in BC development. We previously reported that methyl-oxazolomycin A, a natural compound isolated from Streptomyces sp.

Understanding the disease experiences of thyroid cancer survivors with distant metastases: A qualitative descriptive study.

Purpose: Thyroid cancer is often accompanied by a favorable prognosis; however, its survivors with distant metastasis experience significant physical and psychological challenges. To better understand their challenges, in this study, we investigated the experience of thyroid cancer survivors with distant metastasis.

Methods: A qualitative descriptive design was applied to 21 survivors of thyroid cancer with distant metastasis in South Korea.

Blocking S1P signaling attenuates brain injury in mice with ischemic stroke.

Introduction: The functions of S1P receptors have been revealed using genetic and pharmacological tools, including the potent non-selective modulator FTY720. However, studies on subtype-specific agonists and antagonists are limited; hence, the role of S1P remains unclear.

Objectives: To identify a novel function of S1P as a pathogenic factor in stroke using a newly developed S1P-selective modulator and S1P knockdown.

Fluorescent calix[4]triazole for selective fluoride anion sensing.

Fluoride ions (F) play an important role in preventing cavities and treating osteoporosis, but excessive exposure can lead to serious health problems such as fluorosis and kidney damage. These dual characteristics highlight the need for selective and sensitive methods to detect fluoride ions for health monitoring. Accordingly, in this study, we investigated the anion-binding ability of Py-CT4, a fluorescent chemosensor in which pyrene is linked to calix[4]triazole an ester linker.

Targeted Digital Health Intervention in End-of-Life and Hospice Care: A Scoping Review.

Aim: Digital health interventions, including health analytics, telehealth, mHealth and digitised healthcare systems, are rapidly advancing and demonstrate effectiveness in palliative care. Although end-of-life (EOL) and hospice care are within palliative care, they differ in outcomes, target populations and delivery systems. This review examines research trends to guide digital health strategies for EOL and hospice care.

Uncharted territory: the arrival of (Zetterstedt, 1850) (Diptera: Psychodidae) in Maritime Antarctica.

Despite increasing awareness of the threats they pose, exotic species continue to arrive in Antarctica with anthropogenic assistance, some of which inevitably have the potential to become aggressively invasive. Here, we provide the first report of the globally cosmopolitan species (Diptera, Psychodidae; commonly known as moth flies) in Antarctica during the austral summer of 2021/2022, with the identification confirmed using traditional taxonomic and molecular approaches. The species was present in very large numbers and, although predominantly associated with the drainage and wastewater systems of Antarctic national operator stations in synanthropic situations, it was also present in surrounding natural habitats.

Dorsoradial ligament reconstruction versus imbrication for restoring trapeziometacarpal joint stability: a comparative biomechanical study.

The unique saddle articulation of the trapeziometacarpal joint allows for a wide range of motion necessary for routine function of the thumb. Inherently unstable characteristics of the joint can lead painful instability. In this study, we modified a surgical dorsal ligament reconstruction technique for restoring trapeziometacarpal joint stability.

Improving patient satisfaction based on service quality in clinical trials: A cross-sectional study.

Background: Participants' satisfaction is an important factor in securing competitiveness in clinical trials. In many industries, such as healthcare, customer service quality has been analyzed to increase customer satisfaction. However, no study so far has attempted to measure participants' perceptions of service quality in the clinical trial area and identify its effect on participant satisfaction.

Development and Feasibility Evaluation of a Family-Centred Neonatal End-of-Life Care Protocol.

Aim: To develop a family-centred end-of-life care protocol and evaluate its feasibility.

Design: The draft protocol was created by integrating literature review results and existing protocols and interviewing bereaved parents. A Delphi study and an experts' review were conducted to refine the draft, followed by feasibility testing with neonatal intensive care unit nurses.

Incremental Discourse-Update Constrains Number Agreement Attraction Effect.

While a large body of work in sentence comprehension has explored how different types of linguistic information are used to guide syntactic parsing, less is known about the effect of discourse structure. This study investigates this question, focusing on the main and subordinate discourse contrast manifested in the distinction between restrictive relative clauses (RRCs) and appositive relative clauses (ARCs) in American English. In three self-paced reading experiments, we examined whether both RRCs and ARCs interfere with the matrix clause content and give rise to the agreement attraction effect.

RETRACTED: Evaluating cardiac risks of TASER: An in-depth case study through probable current analysis.

This study investigates the cardiac safety concerns related to TASER discharges centering on a pivotal case that marked the first TASER-related fatality in South Korea. Employing Pratt et al.'s theoretical framework, the research evaluates the potential for ventricular fibrillation (VF) from these discharges.

How Do We Approach Quality Care for Patients from Middle Eastern Countries? A Phenomenological Study of Korean Nurses' Experiences.

Purpose: Although more people from Middle Eastern countries are visiting South Korea for medical treatment, Korean nurses lack experience in treating them. Understanding and describing Korean nurses' experiences can help them provide quality care to these patients by enhancing their competency in culturally appropriate care. This study described the experiences of nurses who provide care to Middle Eastern patients in clinical settings in South Korea.

Risk factors for postoperative delirium in patients with cardiac surgery.

Patients admitted to the intensive care unit (ICU) after cardiac surgery are at high risk of delirium due to a variety of factors. This study aimed to identify the incidence of postoperative delirium in adult patients with cardiac surgery and its risk factors, such as characteristics of subjects, disease and treatment-related, as well as nursing-related characteristics. The study was performed on adult patients who underwent cardiac surgery at Y University Hospital in D city; a total of 195 patients met the inclusion criteria.

Stretchable Heat Transfer Eco-Materials: Mesogen Grafted NR-Based Nanocomposites with High Thermal Conductivity and Low Dielectric Constant.

Biomass-based functional polymers have received significant attention across various fields, in view of eco-friendly human society and sustainable growth. In this context, there are efforts to functionalize the biomass polymers for next-generation polymer materials. Here, stretchable heat transfer materials are focused on which are essential for stretchable electronics and future robotics.

Effect of nanoarray density on enhanced electron transfer efficiency and analytical sensitivity for electrochemical immunosensors.

The fabrication of ordered nanoarray electrode (NAE) using UV imprinting and their application as electrochemical (EC) immunosensor is described in this study. Especially, the influence of the array density factors on the performance of NAE was characterized electrochemically and compared with flat-electrode. Low-density (hole: 200 nm, hole space = 600 nm), medium-density (hole: 200 nm, hole space = 400 nm), and high-density NAE (hole: 200 nm, hole space = 200 nm) which have the same active area were fabricated and their redox cycling was compared with empirical results.