Restless Legs Syndrome During Pregnancy and Puerperium.

Pregnancy is a significant risk factor for the development of Restless Legs Syndrome. Apart from it's negative impact on sleep and general quality of life, RLS is also associated with pregnancy complications and negative outcomes. To elucidate the prevalence, trajectory, severity, and risk factors of RLS throughout pregnancy and the postpartum period we analysed data from the multicenter Life-ON Cohort Study (NCT02664467) which recruited 439 pregnant women in the 10-15th gestational week and followed them up until 12 months after delivery.

Sleep-related breathing disorders during pregnancy: A systematic review and meta-analysis.

This systematic review analyzed 37 studies on sleep-disordered breathing during pregnancy, involving over 7000 women, predominantly pregnant, with a subgroup of non-pregnant controls. Most studies were conducted in the United States, using in-laboratory polysomnography and focusing on the third trimester. The meta-analysis estimated a prevalence of nearly 20 %, although results showed considerable heterogeneity, reflecting variations in study methodologies, diagnostic criteria, and sample characteristics.

Spinal cord stimulation in severe pharmacoresistant restless legs syndrome-two case reports.

Restless legs syndrome is a prevalent, sleep-related sensorimotor disorder with relevant impact on the patients' quality of life. For patients suffering from severe, pharmacoresistant restless legs syndrome, few therapeutic options remain to alleviate symptoms. In this case series, two patients with severe, pharmacoresistant restless legs syndrome were treated with epidural spinal cord stimulation and repeatedly assessed with polysomnography, including sleep structure and periodic limb movements as objective biomarkers not subject to placebo effects, during a 6-month follow-up period.

Sustained remission from perinatal depression after bright light therapy: A pilot randomised, placebo-controlled trial.

Objective: Perinatal depression (PND) is a severe complication of pregnancy, affecting both mothers and newborns. Bright light therapy (BLT) has only been tested in a few studies for treating either antenatal or postnatal depression. We conducted a pilot trial to investigate the efficacy and safety of BLT for PND occurring at any time across the perinatal period.

Polysomnographic features of pregnancy: A systematic review.

Symptoms of sleep disturbances are common among pregnant women and generally worsen across gestation. Pregnancy-related sleep disorders are not only associated with a poor quality of life of the affected mothers, but also with adverse perinatal outcomes, including perinatal depression, gestational diabetes, preeclampsia, and preterm birth. The current knowledge about the impact of sleep disorders during pregnancy largely derives from the results of sleep surveys conducted in various populations.

A New Prospective, Home-Based Monitoring of Motor Symptoms in Parkinson's Disease.

Background: Subjective symptoms, which are retrospectively assessed during clinical interviews in the office, may be influenced by patient recall in Parkinson's disease (PD). Prospective collection of subjective data might be an effective tool to overcome this bias.

Objective: We investigated the correspondence between prospectively and retrospectively assessed motor symptoms in PD.

Leg Movement Activity During Sleep in Adults With Attention-Deficit/Hyperactivity Disorder.

To conduct a first detailed analysis of the pattern of leg movement (LM) activity during sleep in adult subjects with Attention-Deficit/Hyperactivity Disorder (ADHD) compared to healthy controls. Fifteen ADHD patients and 18 control subjects underwent an in-lab polysomnographic sleep study. The periodic character of LMs was evaluated with established markers of "periodicity," i.

Non-24-Hour Sleep-Wake Disorder Revisited - A Case Study.

The human sleep-wake cycle is governed by two major factors: a homeostatic hourglass process (process S), which rises linearly during the day, and a circadian process C, which determines the timing of sleep in a ~24-h rhythm in accordance to the external light-dark (LD) cycle. While both individual processes are fairly well characterized, the exact nature of their interaction remains unclear. The circadian rhythm is generated by the suprachiasmatic nucleus ("master clock") of the anterior hypothalamus, through cell-autonomous feedback loops of DNA transcription and translation.