We reported a rare case of patient affected by pleural lipoma, studied with ultrasound, X-rays, CT, and MRI examination, with both conventional and functional MR imaging modality (DWI), in order to highlight the diagnostic contribution of the DWI sequence. It is necessary to make an adequate evaluation with dedicated imaging to make a correct differential diagnosis from the corresponding malignant forms which would require more radical treatment. In this case we evaluated the effectiveness of the DWI sequence in reaching the correct diagnosis.
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